{"id":241,"date":"2025-06-11T13:37:31","date_gmt":"2025-06-11T13:37:31","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=241"},"modified":"2025-08-08T13:57:10","modified_gmt":"2025-08-08T13:57:10","slug":"adenovirusuri-serologie","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/adenovirusuri-serologie\/","title":{"rendered":"Adenovirusuri-serologie"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<h2><strong>Informa\u021bii generale Adenovirusuri-serologie<\/strong><\/h2>\n<p>Adenovirusurile sunt virusuri ADN \u00eent\u00e2lnite la animale dar \u0219i la om (apar frecvent at\u00e2t la adul\u021bi, c\u00e2t \u0219i la copii). Exist\u0103 mai mult de 100 de tipuri serologice diferite de adenovirus, cu 49 de tipuri, la om. Virusul infecteaz\u0103 o serie de organe, dar majoritatea infec\u021biilor sunt asimptomatice<sup>1<\/sup>. Familia Adenoviridae se \u00eemparte \u00een dou\u0103 genuri: adenovirusurile aviare (aviadenovirusurile) \u0219i adenovirusuri mamifere (mastadenovirusurile)<sup>1<\/sup>. Adenovirusurile reprezint\u0103 aproximativ 10% din bolile legate de febr\u0103 \u0219i infec\u021biile respiratorii acute la copii \u0219i sunt o cauz\u0103 frecvent\u0103 a <a href=\"https:\/\/www.synevo.ro\/sindromul-diareic-forme-de-diaree\/\" data-wpel-link=\"internal\">diareei<\/a>.<\/p>\n<p>Virusul se r\u0103sp\u00e2nde\u0219te prin pic\u0103turi aerosolizate, inoculare direct\u0103 la nivel conjunctival ocular, expunere la \u021besutul infectat, prin s\u00e2nge \u0219i pe cale fecal-oral\u0103. \u00cen general, infec\u021biile cu adenovirus sunt autolimitate la indivizii imunocompromi\u0219i, care necesit\u0103 exclusiv m\u0103suri de sus\u021binere. Cu toate acestea, la persoanele imunodeprimate, spectrul bolii este mult mai extins, av\u00e2nd o evolu\u021bie grav\u0103<sup>2,3<\/sup>.<\/p>\n<p>Infec\u021bia cu adenovirus este cea mai frecvent\u0103 la \u00eenceputul prim\u0103verii sau al iernii, dar poate ap\u0103rea \u0219i pe tot parcursul anului, f\u0103r\u0103 o sezonalitate distinct\u0103<sup>3,5<\/sup>. Susceptibilitatea la copii este cel mai adesea \u00eentalnit\u0103 la v\u0103rste cuprinse \u00eentre \u00a06 luni p\u00e2n\u0103 la 2 ani, dar poate s\u0103 apar\u0103 \u0219i la copiii cu v\u00e2rste cuprinse \u00eentre 5 p\u00e2n\u0103 la 9 ani.<\/p>\n<p>Perioada de incubare dureaz\u0103 de la 2 la 14 zile. Persoanele infectate transmit adenovirusurile prin fluidele corporale, cum ar fi mucusul \u0219i fecalele. Infec\u021bia se poate r\u0103sp\u00e2ndi prin contact personal str\u00e2ns (\u00eembr\u0103\u021bi\u0219are sau str\u00e2ngere de m\u00e2ini) sau prin aer (prin tuse sau str\u0103nut). \u00cen plus, oamenii pot contracta virusul prin atingerea unui obiect sau a unei suprafa\u021be contaminate \u0219i ulterior prin atingerea gurii, nasului sau ochilor, f\u0103r\u0103 a fi sp\u0103la\u021bi pe m\u00e2ini.<\/p>\n<p>Adenovirusurile pot fi uneori eliminate luni de zile dup\u0103 ce o persoan\u0103 a devenit asimptomatic\u0103; astfel, persoanele infectate cu adenovirus pot fi contagioase, chiar dac\u0103 sunt asimptomatice. \u00cen mod semnificativ, adenovirusul sub form\u0103 latent\u0103 poate fi prezent, ani de zile, \u00een parenchimul renal, \u021besutul limfoid \u0219i \u00een alte \u021besuturi; la pacien\u0163ii imunocompromi\u015fi se poate produce reactivarea infectiei<sup>6,7<\/sup>.<\/p>\n<p>Infec\u021biile cu adenovirus pot fi identificate prin izolarea virusului, detectare de antigen, \u00a0confirmare serologic\u0103 a prezen\u021bei de anticorpi omologi \u0219i prin tehnologie PCR. Tiparea adenovirusului se face de obicei prin metode moleculare. Testele serologice\u00a0 sunt mai pu\u021bin utile \u00eentr-un cadrul clinic acut. P\u00e2n\u0103 la v\u00e2rsta de 4 ani, aproximativ jum\u0103tate din copii au titruri pozitive de anticorpi anti-adenovirus.<\/p>\n<p>Dac\u0103 se urm\u0103re\u0219te un diagnostic serologic, serul trebuie ob\u021binut c\u00e2t mai devreme posibil \u00een decursul clinic al bolii, urmat de un al doilea titru 2-4 s\u0103pt\u0103m\u00e2ni mai t\u00e2rziu. O cre\u0219tere de 4 ori a titrurilor acute la titrurile convalescente va avea o valoare diagnostic\u0103<sup>10<\/sup>.<\/p>\n<h2><strong>Recomand\u0103ri pentru determinarea adenovirusurilor \u2013 serologie<\/strong><\/h2>\n<ul>\n<li>Diagnosticul serologic al infec\u021biei cu adenovirus<sup>8<\/sup><\/li>\n<\/ul>\n<p><strong>Specimen recoltat \u2013 <\/strong>s\u00e2nge venos<sup>8<\/sup><\/p>\n<p><strong>Recipient de recoltare \u2013 <\/strong>vacutainer cu anticoagulant de tip EDTA<sup>8<\/sup><\/p>\n<p><strong>Volum prob\u0103 \u2013 <\/strong>1 mL<sup>8<\/sup><\/p>\n<p><strong>Cauze de respingere a probei<\/strong><sup>9<\/sup><\/p>\n<ul>\n<li>Specimen hemolizat<\/li>\n<li>Specimen lipemic<\/li>\n<li>Specimen contaminat bacterian<\/li>\n<\/ul>\n<p><strong>Metod\u0103 \u2013 <\/strong>ELISA<sup>9<\/sup><\/p>\n<h2><strong>Interval de referin\u021b\u0103 Adenovirusuri-serologie<\/strong><\/h2>\n<ul>\n<li>Adenovirusuri IgG negativ;<\/li>\n<li>Adenovirusuri IgA negativ.<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<ol>\n<li>Lukashev, A. N., Ivanova, O. E., Eremeeva, T. P., &amp; Iggo, R. D. (2008). Evidence of frequent recombination among human adenoviruses. The Journal of general virology, 89(Pt 2), 380\u2013388. <a href=\"https:\/\/doi.org\/10.1099\/vir.0.83057-0\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1099\/vir.0.83057-0<\/a><\/li>\n<li>Smith JG, Wiethoff CM, Stewart PL, Nemerow GR (2010). Adenovirus. Curr Top Microbiol Immunol.;343:195-224. doi: 10.1007\/82_2010_16<\/li>\n<li>Ison MG, Hayden RT (2016). Adenovirus. Microbiol Spectr.;4(4). doi: 10.1128\/microbiolspec.DMIH2-0020-2015.<\/li>\n<li>Usman N, Suarez M. Adenoviruses. (2021) In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [on-line]: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559072\/\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559072\/<\/a> (Accesat la data de 13.11.2021)<\/li>\n<li>Lynch JP 3rd, Kajon AE (2016). Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention. Semin Respir Crit Care Med.;37(4):586-602. doi: 10.1055\/s-0036-1584923.<\/li>\n<li>Sandkovsky, U., Vargas, L., &amp; Florescu, D. F. (2014). Adenovirus: current epidemiology and emerging approaches to prevention and treatment. Current infectious disease reports, 16(8), 416. <a href=\"https:\/\/doi.org\/10.1007\/s11908-014-0416-y\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1007\/s11908-014-0416-y<\/a><\/li>\n<li>Radke JR, Cook JL (2018). Human adenovirus infections: update and consideration of mechanisms of viral persistence. Curr Opin Infect Dis.;31(3):251-256. doi: 10.1097\/QCO.0000000000000451.<\/li>\n<li>Quantitative adenovirus test. [on-line]: <a href=\"https:\/\/diagnostics.roche.com\/global\/en\/products\/params\/quantitative-adenovirus-test.html#productSpecs\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/diagnostics.roche.com\/global\/en\/products\/params\/quantitative-adenovirus-test.html#productSpecs<\/a> (Accesat la data de 13.11.2021)<\/li>\n<li>Tests. Adenovirus Group Antibodies, Quantitative. [on-line]: <a href=\"https:\/\/www.labcorp.com\/tests\/096065\/adenovirus-group-antibodies-quantitative\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.labcorp.com\/tests\/096065\/adenovirus-group-antibodies-quantitative<\/a> (Accesat la data de 20.11.2021)<\/li>\n<li><a href=\"https:\/\/emedicine.medscape.com\/article\/211738-workup#c3\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/emedicine.medscape.com\/article\/211738-workup#c3<\/a><\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Informa\u021bii generale Adenovirusuri-serologie Adenovirusurile sunt virusuri ADN \u00eent\u00e2lnite la animale dar \u0219i la om (apar frecvent at\u00e2t la adul\u021bi, c\u00e2t \u0219i la copii). Exist\u0103 mai mult de 100 de tipuri serologice diferite de adenovirus, cu 49 de tipuri, la om. Virusul infecteaz\u0103 o serie de organe, dar majoritatea infec\u021biilor sunt asimptomatice1. Familia Adenoviridae se \u00eemparte [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[43],"product_tag":[],"class_list":["post-241","product","type-product","status-publish","product_cat-serologie-boli-infectioase","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=241"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=241"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=241"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}