{"id":237,"date":"2025-06-11T13:31:11","date_gmt":"2025-06-11T13:31:11","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&p=237"},"modified":"2025-08-08T13:57:15","modified_gmt":"2025-08-08T13:57:15","slug":"anticorpi-anti-acini-pancreatici","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/anticorpi-anti-acini-pancreatici\/","title":{"rendered":"Anticorpi anti-acini pancreatici"},"content":{"rendered":"
\n
\n

Informatii generale si recomandari \u2013 Anticorpi anti-acini pancreatici<\/strong><\/h2>\n

Autoanticorpii fata de celulele acinare pancreatice constituie un marker specific pentru boala Crohn. Impreuna cu anticorpii anti-Saccharomyces cerevisiae (ASCA) si p-ANCA<\/a> sunt utili in diferenterea serologica a bolii Crohn<\/a> de colita ulceroasa1<\/sup>.<\/p>\n

Prevalenta anticorpilor impotriva pancreasului exocrin in boala Crohn este in medie 39%; \u00a0aceasta creste la 50% in cazul unei evolutii a bolii de peste 2 ani. In colita ulceroasa prezenta acestor anticorpi este redusa iar in alte boli inflamatorii nu a fost demonstrata1;2;3<\/sup>.<\/p>\n

In ceea ce priveste tinta antigenica, s-a dovedit ca anticorpii anti-acini pancreatici recunosc o proteina macromoleculara > 800 kD tripsin-sensibila din secretia pancreatica. Implicarea directa a acestora in patogenia bolii Crohn nu a fost sustinuta de studiile efectuate. Se pare ca nu exista o corelatie a acestor anticorpi cu activitatea sau localizarea bolii insa se asociaza cu un debut precoce2<\/sup>.<\/p>\n

Desi sensibilitatea testului este redusa, specificitatea acestuia este inalta, astfel ca poate fi utilizat pentru documentarea diagnosticului la pacientii cu suspiciune clinica de boala Crohn fara anticorpi circulanti ASCA.<\/p>\n

In plus, studiile efectuate de Lawrence si colaboratorii sai au aratat ca testarea combinata a anticorpilor anti-acini pancreatici, ASCA si pANCA permite o diferentiere mai buna a colitei ulceroase de boala Crohn, in special in forma colonica izolata, in comparatie cu testarea individuala ASCA si pANCA2<\/sup>.<\/p>\n

Pregatire pacient<\/strong><\/h2>\n

\u00e0 jeun (pe nemancate) sau postprandial (dupa mese)1<\/sup>.<\/p>\n

Specimen recoltat<\/strong> \u2013 sange venos1<\/sup>.<\/p>\n

Recipient de recoltare<\/strong> \u2013 vacutainer fara anticoagulant cu\/fara gel separator1<\/sup>.<\/p>\n

Prelucrare necesara dupa recoltare<\/strong> \u2013 se separa serul prin centrifugare1<\/sup>.<\/p>\n

Volum proba<\/strong> \u2013 minim 0.5 mL ser1<\/sup>.<\/p>\n

Cauze de respingere<\/strong> a probei<\/strong> \u2013 ser intens hemolizat, lipemic sau puternic contaminat bacterian1<\/sup>.<\/p>\n

Stabilitate proba<\/strong> \u2013 serul separat este stabil 7 zile la 4\u00b0C; timp mai indelungat la -20 \u00b0C1<\/sup>.<\/p>\n

Metoda <\/strong>\u2013 imunofluorescenta indirecta1<\/sup>.<\/p>\n

Valori de referinta Anticorpi anti-acini pancreatici<\/strong><\/h2>\n

anticorpi anti-acini pancreatici \u2013\u00a0 titru < 1\/101<\/sup>.\u00a0<\/strong><\/p>\n

Interpretarea rezultatelor<\/strong><\/h2>\n

Anticorpii anti-acini pancreatici constituie un marker specific pentru boala Crohn si posibil, pentru insuficienta pancreatica asociata3<\/sup>.<\/p>\n

Bibliografie<\/h2>\n

1. Laborator Synevo. Referinte specifice tehnologiei de lucru utilizate 2010.Ref.Type:catalog.<\/p>\n

2. S Desplat-J\u00e9go, C Johanet, A Escande, J Goetz, N Fabien, N Olsson, E Ballot, J Sarles, JJ Baudon , JC Grimaud, M Veyrac, P Chamouard, RL Humbel. Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicenter study. In World J Gastroenterol 2007 April 28;13(16): 2312-2318.<\/p>\n

3. Stephan R. Targan, Fergus Shanahan, Loren C. Karp. Other novel disease markers of ulcerative colitis and Crohn disease. In Inflammatory Bowel Diseases from Bench to Bedside, 2nd edition, 2003, 415.<\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Informatii generale si recomandari \u2013 Anticorpi anti-acini pancreatici Autoanticorpii fata de celulele acinare pancreatice constituie un marker specific pentru boala Crohn. Impreuna cu anticorpii anti-Saccharomyces cerevisiae (ASCA) si p-ANCA sunt utili in diferenterea serologica a bolii Crohn de colita ulceroasa1. Prevalenta anticorpilor impotriva pancreasului exocrin in boala Crohn este in medie 39%; \u00a0aceasta creste la […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[42,84],"product_tag":[],"class_list":["post-237","product","type-product","status-publish","product_cat-markeri-boli-autoimune","product_cat-markeri-pentru-afectiuni-hepatice-si-gastrointestinale-autoimune","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=237"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=237"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=237"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}