{"id":232,"date":"2025-06-11T12:58:46","date_gmt":"2025-06-11T12:58:46","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=232"},"modified":"2025-08-08T13:57:16","modified_gmt":"2025-08-08T13:57:16","slug":"anticorpi-anti-celule-parietale-gastrice","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/anticorpi-anti-celule-parietale-gastrice\/","title":{"rendered":"Anticorpi anti-celule parietale gastrice"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<h2><strong>Informa\u0163<\/strong><strong>ii generale \u2013 Anticorpi anti-celule parietale gastrice<\/strong><\/h2>\n<p>Boala Addison-Biermer (<a href=\"https:\/\/www.synevo.ro\/anemie-pernicioasa-deficitul-de-vitamina-b12\/\" data-wpel-link=\"internal\">anemia pernicioas\u0103<\/a>) este o afec\u0163iune cronic\u0103 caracterizat\u0103 prin anemie megaloblastic\u0103 \u00eenso\u0163it\u0103 de leziuni degenerative ale mucoasei tractului digestiv precum \u015fi la nivelul sistemului nervos.\u00a0Mecanismul de producere al acestei afec\u0163iuni este reprezentat de absorb\u0163ia intestinal\u0103 deficitar\u0103 a vitaminei B12 prin lipsa factorului intrinsec, instalat\u0103 probabil printr-un mecanism autoimun pe un fond constitu\u0163ional particular.<\/p>\n<p>Absorb\u0163ia vitaminei B12 este condi\u0163ionat\u0103 la om de prezen\u0163a factorului intrinsec (FI), o glicoprotein\u0103 secretat\u0103 de celulele parietale din regiunea fundic\u0103 a stomacului, care leag\u0103 cu mare afinitate vitamina B12 eliberat\u0103 prin digestie. Complexul vitamina B12-factor intrinsec este endocitat la nivelul celulelor ileale<sup>5<\/sup>.<\/p>\n<p>Pe l\u00e2ng\u0103 gastrit\u0103, care apare ca o cauz\u0103 primar\u0103 posibil\u0103 a <a href=\"https:\/\/www.synevo.ro\/anemia-megaloblastica-cauze-si-cum-o-tratam\/\" data-wpel-link=\"internal\">anemiei megaloblastice<\/a>, rolul factorilor imunologici este sugerat \u00een primul r\u00e2nd de prezen\u0163a \u00een serul bolnavilor a anticorpilor anti-celule parietale gastrice. Ace\u015fti autoanticorpi sunt depista\u0163i la aproximativ 90% dintre pacien\u0163ii cu anemie pernicioas\u0103, afec\u0163iune care reprezint\u0103 ultimul stadiu al atrofiei autoimune de mucoas\u0103 gastric\u0103<sup>4;5<\/sup>.<\/p>\n<p>Anticorpii interac\u0163ioneaz\u0103 cu subunit\u0103\u0163ile alfa \u015fi beta ale H \/K-ATP-azei, o enzim\u0103 prezent\u0103 la nivelul membranei, iar inflama\u0163ia mediat\u0103 autoimun duce la distruc\u0163ia celulelor parietale gastrice, cu reducerea produc\u0163iei de factor intrinsec \u015fi \u00een consecin\u0163\u0103 sc\u0103derea absorb\u0163iei intestinale de vitamina B12<sup>1<\/sup>.<\/p>\n<h2><strong>Recomand\u0103ri pentru determinarea anticorpilor <\/strong><strong>anti\u2013celule<\/strong> <strong>parietale gastrice<\/strong><\/h2>\n<ul>\n<li>evaluarea pacien\u0163ilor suspecta\u0163i de anemie pernicioas\u0103 sau deficit imun de vitamina B12, cu sau f\u0103r\u0103 anemie megaloblastic\u0103<sup>4<\/sup>.<\/li>\n<\/ul>\n<h2><strong>Preg\u0103tire pacient<\/strong><\/h2>\n<p>nu este necesar\u0103<sup>2<\/sup>.<\/p>\n<p><strong>Specimen recoltat<\/strong> \u2013 s\u00e2nge venos<sup>2<\/sup>.<\/p>\n<p><strong>Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>2<\/sup>.<\/p>\n<p><strong>Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong>\u2013 se separ\u0103 serul prin centrifugare<sup>2<\/sup>.<\/p>\n<p><strong>Volum prob\u0103<\/strong> \u2013 minim 0.5 mL ser<sup>2<\/sup>.<\/p>\n<p><strong>Cauze de respingere a probei<\/strong> \u2013 ser hemolizat, intens lipemic sau contaminat bacterian<sup>2<\/sup>.<\/p>\n<p><strong>Stabilitate prob\u0103 <\/strong>\u2013 serul separat este stabil 4 zile la temperatura camerei,\u00a014 zile 2-8\u00b0C; dou\u0103 luni la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i<sup>2<\/sup>.<\/p>\n<p><strong>Metod\u0103 <\/strong>\u2013 imunofluorescen\u0163\u0103 indirect\u0103<sup>2<\/sup>.<\/p>\n<h2><strong>Valori de referin\u0163\u0103 Anticorpi anti-celule parietale gastrice<\/strong><\/h2>\n<p>Anticorpi anti-celule parietale gastrice: negativ<sup>2<\/sup>.<\/p>\n<h2><strong>Interpretarea rezultatelor<\/strong><\/h2>\n<div>Un rezultat pozitiv indic\u0103 prezen\u0163a anticorpilor anti\u2013celule parietale gastrice de tip IgG \u015fi sugereaz\u0103 posibilitatea existen\u0163ei anemiei pernicioase sau a altor boli autoimune asociate<sup>4<\/sup>. Autoanticorpii sunt depista\u0163i la aproximativ 90% dintre pacien\u0163ii cu anemie pernicioas\u0103 \u015fi la 30% dintre rudele de gradul I ale acestor pacien\u0163i<sup>3<\/sup>.<\/div>\n<div><\/div>\n<div>Anticorpii anti-celule parietale gastrice sunt \u00eent\u00e2lni\u0163i \u015fi \u00een alte boli autoimune cum ar fi: tiroidita autoimun\u0103 Hashimoto, miastenie gravis, diabet zaharat de tip 1, boala Addison, alopecia areata, <a href=\"https:\/\/www.synevo.ro\/vitiligo-cauza-a-depigmentarii-pielii\/\" target=\"_blank\" rel=\"noopener\" data-wpel-link=\"internal\">vitiligo<\/a> etc<sup>3;5<\/sup>.<\/div>\n<div><\/div>\n<div>Nivelul de anticorpi anti-celule parietale gastrice nu este corelat cu severitatea bolii la pacien\u0163ii cu gastrit\u0103 cronic\u0103 autoimun\u0103 sau cu alte afec\u0163iuni autoimune.<\/div>\n<div>Prevalen\u0163a acestor anticorpi cre\u015fte cu v\u00e2rsta la popula\u0163ia s\u0103n\u0103toas\u0103, de la aproximativ 2,5% la grupa de v\u00e2rst\u0103 30\u201339 de ani, la 9,6% \u00een decada a 8-a de via\u0163\u0103<sup>5<\/sup>.<\/div>\n<div>Un rezultat negativ nu exclude posibilitatea existen\u0163ei anemiei pernicioase<sup>4<\/sup>.<\/div>\n<div><\/div>\n<div><strong>Limite \u015fi interferen\u0163e<\/strong><\/div>\n<div>Prezen\u0163a complexelor imune circulante \u00een serul pacien\u0163ilor poate determina rezultate fals-pozitive prin interac\u0163iuni nespecifice. Nu au fost stabilite performan\u0163ele acestei determin\u0103ri \u00een pediatrie<sup>2;3;4<\/sup>.<\/div>\n<p>&nbsp;<\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<div>1. Callaghan JM, Khan MA, Alderuccio F, et al: Alpha and beta subunits of gastric H \/K-ATPase are concordantly targeted by parietal cell autoantibodies associated with autoimmune gastritis. Autoimmun 1993;16(4):289-295.<\/div>\n<div>2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog.<\/div>\n<div>3. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Antiparietal Cell Antibodies, <a href=\"https:\/\/www.labcorp.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.labcorp.com<\/a> 2010. Ref Type: Internet Communication.<\/div>\n<div>4. Mayo Clinic\/Mayo Medical Laboratories Test Catalogs and Guides. Test Catalog: Parietal Cells Antibodies, IgG, Serum. <a href=\"https:\/\/www.mayomedicallaboratories.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.mayomedicallaboratories.com<\/a>.Ref Type: Internet Communication.<\/div>\n<div>5. Radu P\u0103un. Tratat de medicina intern\u0103. Hematologie, vol 1, Ed.1997, 630-647.<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Informa\u0163ii generale \u2013 Anticorpi anti-celule parietale gastrice Boala Addison-Biermer (anemia pernicioas\u0103) este o afec\u0163iune cronic\u0103 caracterizat\u0103 prin anemie megaloblastic\u0103 \u00eenso\u0163it\u0103 de leziuni degenerative ale mucoasei tractului digestiv precum \u015fi la nivelul sistemului nervos.\u00a0Mecanismul de producere al acestei afec\u0163iuni este reprezentat de absorb\u0163ia intestinal\u0103 deficitar\u0103 a vitaminei B12 prin lipsa factorului intrinsec, instalat\u0103 probabil printr-un mecanism [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[82,42],"product_tag":[],"class_list":["post-232","product","type-product","status-publish","product_cat-autoanticorpi-in-anemia-pernicioasa","product_cat-markeri-boli-autoimune","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=232"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=232"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=232"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}