{"id":231,"date":"2025-06-11T12:57:27","date_gmt":"2025-06-11T12:57:27","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=231"},"modified":"2025-08-08T13:57:17","modified_gmt":"2025-08-08T13:57:17","slug":"anticorpi-anti-bp-180-pemfigoid-bulos","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/anticorpi-anti-bp-180-pemfigoid-bulos\/","title":{"rendered":"Anticorpi anti-BP 180 (pemfigoid bulos)"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<h2><b>Informa\u021b<\/b><b>ii generale Anticorpi anti-BP 180 (pemfigoid bulos)<\/b><\/h2>\n<p>Pemfigoidul include un grup de boli autoimune localizate la nivelul tegumentelor \u0219i mucoaselor ce se caracterizeaz\u0103 prin prezen\u021ba unor vezicule situate subepidermal sau subepitelial \u0219i anticorpi IgG anti-membran\u0103 bazal\u0103 \u00een ser. Din aceast\u0103 categorie fac parte: pemfigoidul bulos, herpesul gestationis \u0219i pemfigoidul cicatricial.<\/p>\n<p>Pemfigoidul bulos este o boal\u0103 cronic\u0103 pruriginoas\u0103 debilitant\u0103, ce apare \u00een principal la persoanele \u00een v\u00e2rst\u0103 \u0219i este caracterizat\u0103 prin dezvoltarea unor vezicule pe o zon\u0103 eritematoas\u0103 sau urticarian\u0103. Erup\u021bia este de obicei generalizat\u0103. Au fost descrise mai multe asocieri ale pemfigoidului bulos cu alte afec\u021biuni, dar probabil c\u0103 acestea sunt \u00eent\u00e2mpl\u0103toare. De asemenea nu a putut fi demonstrat\u0103 asocierea cu procese maligne<sup>1<\/sup>.<\/p>\n<p>Anticorpii IgG anti-membran\u0103 bazal\u0103 se g\u0103sesc \u00een serul a 80% dintre pacien\u021bi, dar \u0219i local la nivelul membranei bazale, unde se pot observa depozite lineare de IgG \u0219i C3<sup>1;2;3<\/sup>.<\/p>\n<p>\u00cen pemfigoid, anticorpii IgG se leag\u0103 de proteine specifice ce intr\u0103 \u00een alc\u0103tuirea unor complexe de adeziune celula-matrice \u2013 hemidesmozomi \u2013 \u0219i activeaz\u0103 complementul. In urma reac\u021biei dintre anticorpi \u0219i moleculele din componenta jonc\u021biunii celulare sunt eliberate numeroase substan\u021be chemotactice care atrag la acest nivel celulele inflamatorii; celulele elibereaz\u0103 proteaze \u0219i diver\u0219i mediatori, care degradeaz\u0103 hemidesmozomii \u0219i determin\u0103 o separare dermo-epidermic\u0103.<\/p>\n<p>Tinta autoanticorpilor serici sunt proteinele transmembranare BP230 \u0219i BP180 (BPAG1 \u0219i BPAG2), denumite astfel deoarece greutatea molecular\u0103 a acestor antigene este 230 kD \u0219i respectiv, 180 kD. Se consider\u0103 c\u0103 BP180 reprezint\u0103 \u021binta direct\u0103 a autoanticorpilor datorit\u0103 localiz\u0103rii sale de-a lungul membranei bazale, \u00een timp ce anticorpii anti-BP230 sunt produ\u0219i secundar<sup>1;2<\/sup>.<\/p>\n<p>Pemfigoidul cicatricial afecteaz\u0103 \u00een principal cavitatea bucal\u0103 (gingivita descuamativ\u0103) \u0219i zona ocular\u0103 (conjunctivita la debut care dezvolt\u0103 \u00een timp aderen\u021be fibroase conjunctivale, obliterarea sacului conjunctival, xeroftalmie, opacifierea \u0219i perfora\u021bia corneei \u0219i \u00een final orbire). Pacien\u021bii prezint\u0103 acela\u0219i tip de anticorpi IgG circulan\u021bi ca \u0219i cei cu pemfigus generalizat<sup>1<\/sup>.<\/p>\n<p>De\u0219i diferitele boli cutanate buloase au anumite caracteristici specifice care le disting, de cele mai multe ori manifest\u0103rile clinice sunt atipice \u0219i se suprapun cu alte afec\u021biuni. Depistarea anticorpilor anti-membran\u0103 bazal\u0103 \u00een ser este extrem de sensibil\u0103 \u0219i specific\u0103 pentru pemfigoid \u0219i reprezint\u0103 un element important \u00een diagnosticarea acestei afec\u021biuni.<\/p>\n<p>Diagnosticul \u00a0prompt \u0219i precis este util \u00een stabilirea tratamentului, minimizarea sechelelor bolii, comorbidit\u0103\u021bii \u0219i disconfortului pacientului.<\/p>\n<p>Identificarea antigenelor BP180 \u0219i BP230 a condus la dezvoltarea de teste ELISA cu sensibilitate \u0219i specificitate \u00eenalte<sup>2<\/sup>.<\/p>\n<h2><b>Recomand\u0103ri pentru determinarea anticorpilor anti-BP180<\/b><b> <\/b><\/h2>\n<ul>\n<li>diagnosticul \u0219i monitorizarea r\u0103spunsului terapeutic al pacien\u021bilor cu pemfigoid<sup>2<\/sup>.<b><\/b><\/li>\n<\/ul>\n<h2><b>Preg\u0103tire pacient<\/b><\/h2>\n<p><b>\u00a0<\/b>nu este necesar\u0103 o preg\u0103tire special\u0103<sup>3<\/sup>.<\/p>\n<p><b>Specimen recoltat <\/b>\u2013 s\u00e2nge venos<sup>3<\/sup>.<\/p>\n<p><b>Recipient de recoltare <\/b>\u2013 vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator<sup>3<\/sup>.<\/p>\n<p><b>Prelucrare necesar\u0103 dup\u0103 recoltare<\/b> \u2013 se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C, la -20\u00b0C sau la -70\u00b0C<sup>3<\/sup>.<\/p>\n<p><b>Volum prob\u0103<\/b> \u2013 minim 2 mL ser<sup>3<\/sup>.<\/p>\n<p><b>Cauze de respingere<\/b> <b>a probei: <\/b>specimen hemolizat, ser lipemic sau contaminat bacterian<sup>3<\/sup>.<b><\/b><\/p>\n<p><b>Stabilitate prob\u0103 <\/b>\u2013<b> <\/b>serul separat este stabil 7 zile 2-8\u00b0C; timp \u00eendelungat la -20\u00b0C; nu decongela\u021bi\/recongela\u021bi<sup>3<\/sup>.<\/p>\n<p><b>Metod\u0103 <\/b>\u2013 ELISA<sup>3<\/sup>.<\/p>\n<h2><b>Valori de referin\u021b\u0103 Anticorpi anti-BP 180 (pemfigoid bulos)<\/b><\/h2>\n<p>&lt;20 U\/mL<sup>3<\/sup>. <b><\/b><\/p>\n<h2><b>Interpretarea rezultatelor<\/b><\/h2>\n<div>Anticorpii anti-BP180 sunt prezen\u021bi la majoritatea pacien\u021bilor cu pemfigoid.<\/div>\n<div>La cei mai mul\u021bi dintre pacien\u021bi nivelurile de anticorpi se coreleaz\u0103 cu activitatea bolii, pacien\u021bii cu forme severe prezent\u00e2nd \u00een general concentra\u021bii ridicate ale anticorpilor. De asemenea, ameliorarea clinic\u0103 este asociat\u0103 cu sc\u0103derea nivelului de anticorpi<sup>2<\/sup>.<\/div>\n<div><\/div>\n<div><b>Limite \u0219i interferen\u021be<\/b><\/div>\n<div>Un rezultat pozitiv trebuie interpretat \u00eentotdeauna \u00een contextul clinic al pacien\u021bilor<sup>2<\/sup>.<\/div>\n<p>&nbsp;<\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<div>1.\u00a0\u00a0\u00a0 Thomas P. Habif. Vesicular and Bullous Diseases. In Clinical Dermatology, Mosby, 4th Edition, 2004, 567-572<\/div>\n<div>2.\u00a0\u00a0\u00a0 Mayo Clinic. Mayo Medical Laboratories. Test Catalog. Bullous Pemphigoid, BP180 &amp;\u00a0 BP230, IgG Antibodies, Serum. Cutaneous Immunoflourescence Antibodies, Serum. <a href=\"https:\/\/www.mayomedicallaboratories.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.mayomedicallaboratories.com<\/a>. Ref Type: Internet Communication.<\/div>\n<div>3.\u00a0\u00a0\u00a0 Laborator Synevo. Referin\u021bele specifice tehnologiei de lucru utilizate 2013. Ref Type: Catalog.<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Informa\u021bii generale Anticorpi anti-BP 180 (pemfigoid bulos) Pemfigoidul include un grup de boli autoimune localizate la nivelul tegumentelor \u0219i mucoaselor ce se caracterizeaz\u0103 prin prezen\u021ba unor vezicule situate subepidermal sau subepitelial \u0219i anticorpi IgG anti-membran\u0103 bazal\u0103 \u00een ser. Din aceast\u0103 categorie fac parte: pemfigoidul bulos, herpesul gestationis \u0219i pemfigoidul cicatricial. Pemfigoidul bulos este o boal\u0103 [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[81,42],"product_tag":[],"class_list":["post-231","product","type-product","status-publish","product_cat-autoanticorpi-in-afectiunile-dermatologice","product_cat-markeri-boli-autoimune","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=231"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=231"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=231"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}