{"id":229,"date":"2025-06-11T12:54:32","date_gmt":"2025-06-11T12:54:32","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&p=229"},"modified":"2025-08-08T13:57:23","modified_gmt":"2025-08-08T13:57:23","slug":"anti-tiroglobulina","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/anti-tiroglobulina\/","title":{"rendered":"Anti-tiroglobulina"},"content":{"rendered":"
\n

Informa\u0163ii generale: Anti-tiroglobulina<\/strong><\/h2>\n
Tiroglobulina este sintetizat\u0103 \u00een glanda tiroid\u0103, fiind principalul component din lumenul foliculului tiroidian. \u00cempreun\u0103 cu peroxidaza specific\u0103 tiroidei (TPO<\/a>) de\u0163ine un rol esen\u0163ial \u00een iodinarea L-tirozinei \u015fi \u00een formarea hormonilor tiroidieni T3<\/a> \u015fi T4<\/a>. At\u00e2t tiroglobulina c\u00e2t \u015fi TPO sunt poten\u0163ial autoantigenice.<\/div>\n
Niveluri crescute de anticorpi anti-tiroglobulin\u0103 \u015fi anti-TPO<\/a> sunt sugestive pentru\u00a0tiroidita cronic\u0103 Hashimoto<\/a>.<\/div>\n
Anticorpii fa\u0163\u0103 de tiroglobulin\u0103 pot fi depista\u0163i la 70-80% din pacien\u0163ii cu tiroidit\u0103 autoimun\u0103, inclusiv boala Hashimoto, \u015fi la aproximativ 30% din pacien\u0163ii cu boala Graves<\/a>1;2<\/sup>.<\/div>\n
<\/div>\n

Recomand\u0103ri pentru determinarea anticorpilor anti-tiroglobulin\u0103 <\/strong><\/h2>\n

Suspiciune de tiroidit\u0103 autoimun\u0103 cu anti-TPO<\/a> negativ; boala Graves f\u0103r\u0103 infiltrat limfocitar; monitorizarea pacien\u0163ilor cu tiroidit\u0103 Hashimoto; excluderea posibilelor interferen\u0163e analitice generate de anticorpii anti-tiroglobulin\u0103 la determinarea tiroglobulinei1;2<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate)2<\/sup>.<\/p>\n

Specimen recoltat <\/strong>\u2013 s\u00e2nge venos2<\/sup>.<\/p>\n

Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator2<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong>\u2013 se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C2<\/sup>.<\/p>\n

Volum prob\u0103<\/strong> \u2013 minim 0.5 mL ser2<\/sup>.<\/p>\n

Cauze de respingere<\/strong> a probei<\/strong> \u2013 specimen intens hemolizat2<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/strong>\u2013 serul separat este stabil 3 zile la +2\u00b0C \u2013 +8\u00b0C; 1 lun\u0103 la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i2<\/sup>.<\/p>\n

Metod\u0103 <\/strong>\u2013 imunochimic\u0103 cu detec\u0163ie prin electrochemiluminiscen\u0163\u0103 (ECLIA)2<\/sup>.<\/p>\n

Valori de referin\u0163\u0103 Anti-tiroglobulina:\u00a0<\/strong><\/h2>\n

< 3 luni: < 146 (UI\/mL)
\n3 \u2013 12 lun: < 130 (UI\/mL)<\/p>\n

1 \u2013 6 ani: < 38 (UI\/mL)
\n6 \u2013 11 ani:\u00a0 < 37 (UI\/mL)
\n11 \u2013 20 ani: < 64 (UI\/mL)
\n> 20 ani: < 115 (UI\/mL)<\/p>\n

Factor de conversie:\u00a0 UI\/ml = kUI\/l<\/p>\n

Limite \u015fi interferen\u0163e<\/strong><\/p>\n

Testul se poate pozitiva \u015fi \u00een alte afec\u0163iuni autoimune, \u00een special \u00een anemia pernicioas\u0103.<\/a> Ace\u015fti autoanticorpi pot fi prezen\u0163i, \u00eentr-un procent redus, \u015fi la indivizi s\u0103n\u0103to\u015fi, mai ales la femeile v\u00e2rstnice1<\/sup>.<\/p>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Pot produce interferen\u0163e cu unele componente ale kit-ului \u015fi conduce la rezultate neconcludente urm\u0103toarele:<\/p>\n

\u2013 tratamentul cu biotin\u0103 \u00een doze mari (>5 mg\/zi); de aceea se recomand\u0103 ca recoltarea de s\u00e2nge s\u0103 se\u00a0fac\u0103 dup\u0103 minimum 8 ore de la ultima administrare;<\/div>\n
\u2013 titrurile foarte crescute de anticorpi anti-streptavidin\u0103 \u015fi anti-ruteniu2<\/sup>.<\/div>\n
<\/div>\n

\u00a0Bibliografie<\/strong><\/h2>\n
1. Laboratory Corporation of America. Directory of Services and Interpretive Guide. www.labcorp.com<\/a> 2010. Ref Type: Internet Communication<\/div>\n
2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Informa\u0163ii generale: Anti-tiroglobulina Tiroglobulina este sintetizat\u0103 \u00een glanda tiroid\u0103, fiind principalul component din lumenul foliculului tiroidian. \u00cempreun\u0103 cu peroxidaza specific\u0103 tiroidei (TPO) de\u0163ine un rol esen\u0163ial \u00een iodinarea L-tirozinei \u015fi \u00een formarea hormonilor tiroidieni T3 \u015fi T4. At\u00e2t tiroglobulina c\u00e2t \u015fi TPO sunt poten\u0163ial autoantigenice. Niveluri crescute de anticorpi anti-tiroglobulin\u0103 \u015fi anti-TPO sunt sugestive pentru\u00a0tiroidita […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[79,42],"product_tag":[],"class_list":["post-229","product","type-product","status-publish","product_cat-autoanticorpi-in-afectiuni-endocrine-cardiace-renale","product_cat-markeri-boli-autoimune","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=229"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=229"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=229"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}