{"id":228,"date":"2025-06-11T12:53:05","date_gmt":"2025-06-11T12:53:05","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&p=228"},"modified":"2025-08-08T13:57:24","modified_gmt":"2025-08-08T13:57:24","slug":"anticorpi-antispermatozoizi-in-ser","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/anticorpi-antispermatozoizi-in-ser\/","title":{"rendered":"Anticorpi antispermatozoizi \u00een ser"},"content":{"rendered":"

Informa\u0163ii generale \u2013 Anticorpi antispermatozoizi \u00een ser<\/strong><\/h2>\n

Existen\u0163a anticorpilor \u00eendrepta\u0163i \u00eempotriva spermatozoizilor a fost suspectat\u0103 de mult timp. Studii sistematice au demonstrat propriet\u0103\u0163ile imunogene ale celulelor seminale prin eviden\u0163ierea produc\u0163iei de autoanticorpi la b\u0103rba\u0163i sau a izo-anticorpilor la femei. Recent, s-a concluzionat c\u0103 at\u00e2t b\u0103rba\u0163ii, c\u00e2t \u015fi femeile sunt capabili s\u0103 produc\u0103 anticorpi \u00eempotriva spermatozoizilor umani.<\/p>\n

Acest status imunologic alterat poate afecta major fertilitatea. De\u015fi cauzele apari\u0163iei acestor anticorpi nu au fost complet elucidate, anticorpii antispermatozozi sunt recunoscu\u0163i ca un factor semnificativ \u00een inducerea infertilit\u0103\u0163ii prin mecanism imunologic.<\/p>\n

Astfel, anticorpii antispermatozoizi se pot g\u0103si \u00eentr-un procent de 30% la pacien\u0163ii cu infertilitate<\/a> de cauz\u0103 neprecizat\u0103.<\/p>\n

Spermatozoizii sunt separa\u0163i de sistemul imunitar al b\u0103rbatului prin a\u015fa numit\u0103 barier\u0103 hemato-testicular\u0103. C\u00e2nd aceast\u0103 barier\u0103 este compromis\u0103, cum se \u00eent\u00e2mpl\u0103 \u00een cazul traumatismelor testiculare, vasectomiei, obstruc\u0163iei epididimului sau infec\u0163iilor, spermatozoizii trec \u00een circula\u0163ie \u015fi ac\u0163ioneaz\u0103 ca imunogeni. Mecanismul prin care femeile ajung s\u0103 dezvolte \u00een serul lor izo-anticorpi este mai pu\u0163in cunoscut.<\/p>\n

S-a afirmat c\u0103 infec\u0163iile virale sau bacteriene nespecifice ar induce anticorpi care ar reac\u0163iona \u00eencruci\u015fat cu antigenele spermatozoizilor. Recent, a fost luat\u0103 \u00een considerare posibilitatea existen\u0163ei unui proces autoimun asociat cu apari\u0163ia anticorpilor antispermatozoizi.<\/p>\n

Singurii anticorpi care au semnifica\u0163ie clinic\u0103 sunt cei specifici pentru membrana plasmatic\u0103 a spermatozoizilor. Ace\u015fti anticorpi sunt capabili s\u0103 afecteze propriet\u0103\u0163ile de motilitate ale celulelor spermatice \u015fi participarea lor \u00een procesul de fertilizare.<\/p>\n

Astfel, prezen\u0163a anticorpilor interfer\u0103 cu: reac\u0163ia acrozomului, capacita\u0163ia, penetrarea prin mucusul cervical, ata\u015farea spermatozoizilor de ovul, penetrarea efectiv\u0103 a spermatozoizilor \u015fi fertilizarea ovulului1;2<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea anticorpilor antispermatozoizi \u00een ser <\/strong><\/h2>\n

Investigarea cazurilor de infertilitate \u00een urm\u0103toarele situa\u0163ii:<\/p>\n

    \n
  • La b\u0103rba\u0163i<\/strong>:\n
      \n
    • aglutinarea spermatozoizilor \u00een ejaculat;<\/li>\n
    • antecedente de traumatism testicular sau biopsie;<\/li>\n
    • vasectomie;<\/li>\n
    • infec\u0163ii genitale;<\/li>\n
    • leziuni obstructive ductale;<\/li>\n<\/ul>\n<\/li>\n
    • La femei<\/strong>:\n
        \n
      • test postcoital anormal;<\/li>\n
      • antecedente de infec\u0163ii genitale;<\/li>\n
      • absen\u0163a altor cauze de infertilitate1<\/sup>;<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

        Preg\u0103tire pacient <\/strong><\/h2>\n

        \u00e0 jeun sau postprandial2<\/sup>.<\/p>\n

        Specimen recoltat <\/strong>\u2013 s\u00e2nge venos2<\/sup>.<\/p>\n

        Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator2<\/sup>.<\/p>\n

        Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong>\u2013 se separ\u0103 serul prin centrifugare2<\/sup>.<\/p>\n

        Volum prob\u0103<\/strong> \u2013 minim 0.5 mL ser2<\/sup>.<\/p>\n

        Cauze de respingere<\/strong> a probei <\/strong>\u2013 specimen hemolizat sau care nu a fost pastrat la 2-8\u00b0C.<\/p>\n

        Stabilitate prob\u0103 <\/strong>\u2013 3 zile la 2-8\u00b0 C; 1 luna la -20\u00b0C2<\/sup>.<\/p>\n

        Metod\u0103 <\/strong>\u2013 ELISA2<\/sup>.<\/p>\n

        Valori de referin\u0163\u0103 Anticorpi antispermatozoizi \u00een ser<\/strong><\/h2>\n

        0-60 R.U.\/ml<\/p>\n

        Bibliografie:<\/strong><\/p>\n

        1.\u00a0Frances Fischbach. Immunodiagnostics Studies. In A Manual of Laboratory and Diagnostics Tests. Lippincott Williams & Wilkins, USA, 7 ed. 2004, 636-638.<\/div>\n
        2.\u00a0Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate 2010. Ref Type: Catalog<\/div>","protected":false},"excerpt":{"rendered":"

        Informa\u0163ii generale \u2013 Anticorpi antispermatozoizi \u00een ser Existen\u0163a anticorpilor \u00eendrepta\u0163i \u00eempotriva spermatozoizilor a fost suspectat\u0103 de mult timp. Studii sistematice au demonstrat propriet\u0103\u0163ile imunogene ale celulelor seminale prin eviden\u0163ierea produc\u0163iei de autoanticorpi la b\u0103rba\u0163i sau a izo-anticorpilor la femei. Recent, s-a concluzionat c\u0103 at\u00e2t b\u0103rba\u0163ii, c\u00e2t \u015fi femeile sunt capabili s\u0103 produc\u0103 anticorpi \u00eempotriva spermatozoizilor […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[78,42],"product_tag":[],"class_list":["post-228","product","type-product","status-publish","product_cat-anticorpi-antispermatozoizi","product_cat-markeri-boli-autoimune","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=228"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=228"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=228"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}