{"id":220,"date":"2025-06-11T12:40:22","date_gmt":"2025-06-11T12:40:22","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=220"},"modified":"2025-08-08T13:57:33","modified_gmt":"2025-08-08T13:57:33","slug":"11-deoxicorticosteron","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/11-deoxicorticosteron\/","title":{"rendered":"11-deoxicorticosteron"},"content":{"rendered":"<h2><strong>Informa\u021bii generale 11-deoxicorticosteron<\/strong><\/h2>\n<p>Determinarea seric\u0103 a <strong>11-Deoxicorticosteron<\/strong> seric este recomandat\u0103 \u00een evaluarea suspiciunii de tumor\u0103 suprarenalian\u0103 adrenocorticoida voluminoas\u0103.<\/p>\n<p>Este un hormon steroid produs de glanda suprarenala, cu activitate mineralocorticoida, fiind un precuror al aldosteronului. DOC este produs de tumorile suprarenale pure, care sunt foarte rare \u0219i de obicei voluminoase \u0219i maligne. Exista si adenoame adrenocorticoide benigne care produc DOC. Unele neoplasme suprarenale co-secreta androgeni \u0219i estrogeni \u00een plus fa\u021b\u0103 de DOC si pot provoca virilizare la femei sau feminizarea la b\u0103rba\u021bi.<\/p>\n<p>Prezentarea clinic\u0103 tipic\u0103 ar fi aceea a debutului relativ rapid al unei hipertensiuni arteriale marcate, asociate cu hipokaliemie \u0219i niveluri sc\u0103zute de <a href=\"https:\/\/www.synevo.ro\/shop\/aldosteron-seric\/\" data-wpel-link=\"internal\">aldosteron<\/a> \u0219i renin\u0103 \u00een s\u00e2nge. Un nivel ridicat de DOC plasmatic sau tetrahidrodeoxicorticosteron urinar \u0219i o tumor\u0103 suprarenal\u0103 voluminoasa observat\u0103 la CT confirm\u0103 diagnosticul. Secre\u021bia de aldosteron este de obicei suprimat\u0103.<\/p>\n<p>Progesteronul este transformat fie \u00een 17\u03b1-hidroxiprogesteron, \u00een prezen\u021ba 17\u03b1-hidroxilazei, fie \u00een 11-deoxicorticosteron, de catre 21\u03b1-hidroxilaz\u0103. 17\u03b1-hidroxiprogesteron\u0103 este apoi transformat\u0103 \u00een 11-deoxicortizol, \u00een prezen\u021ba 21\u03b1-hidroxilazei; 11-Deoxicortizolul este apoi transformat \u00een prezen\u021ba 11\u03b2-hidroxilazei, \u00een cortisol; 11-Deoxicorticosteronul este transformat \u00een corticosteron \u00een prezen\u021ba 11\u03b2-hidroxilazei<sup>1,2<\/sup>. \u00cen deficitul de 11 beta-hidroxilaz\u0103 1 (CYP11B1), concentra\u021biile serice de <a href=\"https:\/\/www.synevo.ro\/shop\/cortizol-seric\/\" data-wpel-link=\"internal\">cortizol<\/a> vor fi sc\u0103zute.<\/p>\n<p>La recoltarea s\u00e2ngelui, diminea\u021b\u0103, 11-Deoxicortizolul \u0219i 11-deoxicorticosteronul prezint\u0103 concentra\u021bii crescute, de obicei la cel pu\u021bin 2 p\u00e2n\u0103 la 3 ori (mai tipic de 20-300 de ori) fat\u0103 de limita superioar\u0103 a intervalului normal de referin\u021b\u0103. Cre\u0219terile concentra\u021biilor de 11-deoxicortizol sunt de obicei relativ mai mari dec\u00e2t cele ale 11-deoxicorticosteronului, din cauza prezen\u021bei 11 beta-hidroxilazei 2 (CYP11B2)<sup>2<\/sup>.<\/p>\n<p>Din acest motiv, concentra\u021biile serice ale tuturor corticoizilor minerali puternici (corticosteron, 18-hidroxicorticosteron \u0219i aldosteron) sunt de obicei crescute peste intervalul normal de referin\u021b\u0103<sup>2<\/sup>.<\/p>\n<h2><strong>\u00a0<\/strong><strong>Recomand\u0103ri pentru determinarea 11-deoxicorticosteron<\/strong><\/h2>\n<ul>\n<li>Diagnosticul unui deficit suspectat de 11-hidroxilaz\u0103, inclusiv diagnosticul diferen\u021bial al deficitului de 11 beta-hidroxilazei 1 (CYP11B1), fa\u021b\u0103 de deficitul de 11 beta-hidroxilaz\u0103 2 (CYP11B2)<\/li>\n<li>Diagnosticul hiperaldosteronismului sensibil la glucocorticoizi<\/li>\n<li>Evaluarea hiperplaziei suprarenale congenitale la copiii nou-n\u0103scu\u021bi cu screening pozitiv, atunci c\u00e2nd cre\u0219terea 17-hidroxiprogesteronului este moderat\u0103, suger\u00e2nd posibilul deficit de 11-hidroxilaz\u0103<\/li>\n<\/ul>\n<p><strong>Specimen recoltat\u00a0\u2013<\/strong>s\u00e2nge venos (de preferat, recoltat diminea\u021ba)<sup>4<\/sup><\/p>\n<p><strong>Volum prob\u0103\u00a0\u2013 <\/strong>1 mL<\/p>\n<p><strong>Cauze de respingere a probei<\/strong><strong>\u00a0<\/strong>\u2013 specimen hemolizat<sup>4<\/sup><\/p>\n<p><strong>Stabilitate prob\u0103\u00a0\u00a0<\/strong><\/p>\n<p>Proba este stabil\u0103 la frigider (preferabil) \u0219i la congelator timp de 21 de zile, iar la temperatur\u0103 ambiental\u0103 7 zile<sup>4<\/sup>.<\/p>\n<p><strong>Metod\u0103<\/strong><strong>\u00a0\u2013 <\/strong>Cromatografie de lichide cuplat\u0103 cu spectrometrie de mas\u0103 \u00een tandem (LC-MS\/MS)<sup>4<\/sup><\/p>\n<h2><strong>Valori de referin\u021b\u0103\u00a0 11-deoxicorticosteron<\/strong><\/h2>\n<p>m\/f &gt; 18 ani: \u00a0&lt; 0,16 \u00b5g\/l<\/p>\n<p><strong>Limite si interferente<\/strong><sup>4<\/sup><\/p>\n<p>Interpretarea rezultatelor corticoizilor minerali la sugarii cu v\u00e2rsta sub 7 zile: nivelurile de corticoizi minerali sunt adesea substan\u021bial crescute la nou-n\u0103scu\u021bii s\u0103n\u0103to\u0219i \u00een primele c\u00e2teva ore de via\u021b\u0103 \u0219i scad p\u00e2n\u0103 la niveluri aproapiate cu cele ale adultului, \u00a0dup\u0103 prima s\u0103pt\u0103m\u00e2na de viata.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<ol>\n<li>John W. Pelley (2012). 11 \u2013 Metabolism of Steroids and Other Lipids, Editor(s): John W. Pelley, Elsevier\u2019s Integrated Review Biochemistry (Second Edition), W.B. Saunders, Pages 89-98, ISBN 9780323074469, <a href=\"https:\/\/doi.org\/10.1016\/B978-0-323-07446-9.00011-8\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1016\/B978-0-323-07446-9.00011-8<\/a>.<\/li>\n<li>Connell, J. M., Davies, D. L., Fraser, R., &amp; Kenyon, C. J. (1986). Dopamine effects on 11-deoxycorticosterone concentrations in patients with Cushing\u2019s syndrome and in vitro. Clinical endocrinology, 25(4), 427\u2013433. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2265.1986.tb01709.x\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1111\/j.1365-2265.1986.tb01709.x<\/a><\/li>\n<li>Sippell, W. G., M\u00fcller-Holve, W., D\u00f6rr, H. G., Bidlingmaier, F., &amp; Knorr, D. (1981). Concentrations of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, and cortisone determined simultaneously in human amniotic fluid throughout gestation. The Journal of Clinical Endocrinology and Metabolism, 52(3), 385\u2013392. <a href=\"https:\/\/doi.org\/10.1210\/jcem-52-3-385\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1210\/jcem-52-3-385<\/a><\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Test Catalog. [on-line]: <a href=\"https:\/\/www.mayocliniclabs.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.mayocliniclabs.com<\/a> [Accesat la data de 28.04.2021]<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Informa\u021bii generale 11-deoxicorticosteron Determinarea seric\u0103 a 11-Deoxicorticosteron seric este recomandat\u0103 \u00een evaluarea suspiciunii de tumor\u0103 suprarenalian\u0103 adrenocorticoida voluminoas\u0103. Este un hormon steroid produs de glanda suprarenala, cu activitate mineralocorticoida, fiind un precuror al aldosteronului. DOC este produs de tumorile suprarenale pure, care sunt foarte rare \u0219i de obicei voluminoase \u0219i maligne. Exista si adenoame adrenocorticoide [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[36,73],"product_tag":[],"class_list":["post-220","product","type-product","status-publish","product_cat-markeri-endochrini","product_cat-markeri-suprarenalieni","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=220"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=220"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=220"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}