{"id":218,"date":"2025-06-11T12:37:27","date_gmt":"2025-06-11T12:37:27","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=218"},"modified":"2025-08-08T13:57:35","modified_gmt":"2025-08-08T13:57:35","slug":"dihidrotestosteron","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/dihidrotestosteron\/","title":{"rendered":"Dihidrotestosteron"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<p><strong>Aceast\u0103 analiz\u0103 se efectueaz\u0103 conform urm\u0103toarelor specifica\u021bii\/ condi\u021bii:<\/strong><\/p>\n<ul>\n<li><strong>Bucure\u0219ti, Ilfov \u0219i zonele limitrofe: <\/strong>recoltarea se efectueaz\u0103 \u00een intervalul <strong>miercuri \u2013 s\u00e2mb\u0103t\u0103,<\/strong> \u00een timpul programului de recoltare al centrului ales.<\/li>\n<li>Pentru\u00a0<strong>restul \u021b\u0103rii,<\/strong> recoltarea se efectueaz\u0103 \u00een intervalul <strong>miercuri \u2013 vineri, <\/strong>\u00een timpul programului de recoltare al centrului ales.<\/li>\n<\/ul>\n<h2><strong>Informa\u0163ii generale Dihidrotestosteron (DHT)<\/strong><\/h2>\n<p>Dihidrotestosteronul (DHT) este un metabolit biologic activ al testosteronului, produs \u00een principal la nivelul prostatei, dar \u015fi\u00a0\u00een testicule, foliculii pilo\u015fi \u015fi glandele suprarenale. DHT este sintetizat din testosteron\u00a0\u00een urma unei reac\u0163ii de reducere, catalizat\u0103 de 5 \u03b1-reductaza. Dou\u0103 izoenzime au fost descrise: tipul 1 prezent\u00a0\u00een majoritatea \u0163esuturilor din organism, fiind forma predominant\u0103 \u00een glandele sebacee \u015fi tipul 2, izoenzima preponderent\u0103 la nivelul aparatului genital masculin<sup>3<\/sup>.<\/p>\n<p>Este eliberat \u00een circula\u0163ie \u00eencep\u00e2nd din via\u0163a intrauterin\u0103 \u015fi este responsabil pentru formarea caracterelor sexuale secundare masculine, cum ar fi cre\u015fterea p\u0103rului facial \u015fi corporal \u015fi \u00eengro\u015farea vocii. Spre deosebire de testosteron, DHT nu poate fi transformat \u00een estradiol de aromataz\u0103 \u015fi, \u00een consecin\u0163\u0103, poate fi folosit ca antagonist \u00een dezvoltarea tr\u0103s\u0103turilor feminine la b\u0103rba\u0163i. S-a aratat c\u0103 DHT este inactivat \u00een mu\u015fchii scheletici prin ac\u0163iunea 3-\u03b1 hidroxisteroid dehidrogenazei \u015fi deci nu are nici un efect asupra hipertrofiei musculare.<\/p>\n<p>Femeile cu o concentra\u0163ie plasmatic\u0103 crescut\u0103 de DHT pot prezenta unele caractere sexuale secundare androgene, cum ar fi vocea \u00eengro\u015fat\u0103 \u015fi p\u0103rul facial. Circa \u00a035% din pacientele cu <a href=\"https:\/\/www.synevo.ro\/sindromul-ovarelor-polichistice-cauza-infertilitatii\/\" data-wpel-link=\"internal\">sindromul ovarelor polichistice<\/a> au asociate cre\u015fteri ale nivelului seric de DHT.<\/p>\n<p>\u00cen sindromul Klinefelter nivelul DHT este mult mai sc\u0103zut dec\u00e2t la b\u0103rba\u0163ii normali, spre deosebire de hirsutismul idiopatic, \u00een care aproximativ 40% din pacien\u0163i au concentra\u0163ii crescute.<\/p>\n<p>Nivelele serice ale DHT r\u0103m\u00e2n normale odat\u0103 cu \u00eenaintarea \u00een v\u00e2rst\u0103 \u015fi nu se modific\u0103 \u00een hiperplazia benign\u0103 de prostat\u0103 (HBP).<\/p>\n<p>\u00cen condi\u0163ii patologice dihidrotestosteronul este implicat \u00een cre\u015fterea excesiv\u0103 a prostatei \u015fi c\u0103derea p\u0103rului (calvi\u0163ie)<sup>3<\/sup>.<\/p>\n<p>Alopecia androgenic\u0103 afecteaz\u0103 aproape 30% dintre b\u0103rba\u0163ii sub 30 de ani, 50% dintre b\u0103rba\u0163ii peste 50 de ani \u015fi, \u00eentr-un mod surprinz\u0103tor, 40% dintre femeile peste 50 de ani. Este o condi\u0163ie determinat\u0103 genetic la care se adaug\u0103 \u015fi factorul hormonal \u2013 androgenii, \u00een special DHT \u2013 care este necesar pentru progresia bolii. La nivelul scalpului frontal au fost depistate concentra\u0163ii crescute de 5 \u03b1-reductaz\u0103, iar procesele dependente de androgeni se datoreaz\u0103 \u00een principal leg\u0103rii DHT de receptorii specifici. Debutul afec\u0163iunii este gradat.<\/p>\n<p>B\u0103rba\u0163ii prezint\u0103 o r\u0103rire a p\u0103rului \u00een zonele temporale, forma scalpului redefinindu-se \u00een zona anterioar\u0103. Boala evolueaz\u0103 progresiv spre zona frontal\u0103 \u015fi vertex. Femeile prezint\u0103 o c\u0103dere difuz\u0103 a p\u0103rului pe coroan\u0103. Poate s\u0103 apar\u0103 la femei \u015fi o r\u0103rire bitemporal\u0103 a p\u0103rului, dar \u00eentr-un grad mai mic fa\u0163\u0103 de b\u0103rba\u0163i; \u00een general femeile men\u0163in o linie frontal\u0103 a p\u0103rului.<\/p>\n<p>Tratamentul alopeciei androgenice include dou\u0103 preparate care \u015fi-au demonstrat eficien\u0163a \u00eentr-un num\u0103r semnificativ de cazuri: finasterida administrat\u0103 oral (un inhibitor competitiv de 5 \u03b1-reductaz\u0103) \u015fi minoxidilul\u00a0\u00een aplica\u0163ii locale<sup>3<\/sup>.<\/p>\n<h2><strong>Recomand\u0103ri pentru determinarea dihidrotestosteronului<\/strong><\/h2>\n<p>Monitorizarea pacien\u0163ilor trata\u0163i cu inhibitori de 5 \u03b1-reductaz\u0103; evaluarea pacien\u0163ilor cu un posibil deficit de 5 \u03b1-reductaz\u0103<sup>3<\/sup>.<\/p>\n<p>\u00cen unele cancere de prostat\u0103 (mai ales stadiul D) determinarea DHT ar putea fi util\u0103 pentru estimarea r\u0103spunsului la tratamentul antiandrogenic<sup>1<\/sup>.<\/p>\n<p><strong>Preg\u0103tire pacient <\/strong>\u2013\u00e0 jeun (pe nem\u00e2ncate)<sup>2<\/sup>.<\/p>\n<p><strong>Specimen recoltat <\/strong>\u2013 s\u00e2nge venos<sup>2<\/sup>.<\/p>\n<p><strong>Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator<sup>2<\/sup>.<\/p>\n<p><strong>Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong>\u2013se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul proasp\u0103t; dac\u0103 acest lucru nu este posibil, serul se p\u0103streaz\u0103 la 2-8\u00b0C sau la -20\u00b0C<sup>2<\/sup>.<\/p>\n<p><strong>Volum proba<\/strong> \u2013 1 mL ser<sup>2<\/sup>.<\/p>\n<p><strong>Cauze de respingere a probei<\/strong> \u2013 specimen intens hemolizat<sup>2<\/sup>.<\/p>\n<p><strong>Stabilitate prob\u0103 <\/strong>-7 zile la 2-8\u00b0C; 6 luni la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i<sup>2<\/sup>.<\/p>\n<p><strong>Metod\u0103 <\/strong>\u2013 ELISA<sup>2<\/sup>.<\/p>\n<h2><strong>Valori de referin\u0163\u0103 Dihidrotestosteron<\/strong><\/h2>\n<p><strong>B\u0103rba\u0163i:<\/strong>\u00a0 250-999 pg\/mL<br \/>\n<strong>Femei<\/strong>:<br \/>\n\u2013 premenopauz\u0103: 24-368 pg\/mL<br \/>\n\u2013 postmenopauz\u0103: 10-181 pg\/mL<sup>2<\/sup><\/p>\n<h2><strong>Interpretarea rezultatelor<\/strong><\/h2>\n<p>Pacien\u0163ii trata\u0163i cu inhibitori de 5 \u03b1-reductaz\u0103 prezint\u0103 nivele plasmatice sc\u0103zute de DHT. De asemenea prezint\u0103 valori sc\u0103zute\u00a0\u015fi cei cu deficit genetic de 5 alfa-reductaz\u0103 (afec\u0163iune rar\u0103 care afecteaz\u0103 dezvoltarea sexual\u0103 masculin\u0103 \u00eenainte de na\u015ftere \u015fi\u00a0\u00een cursul pubert\u0103\u0163ii)<sup>3<\/sup>.<\/p>\n<p>S-a demonstrat c\u0103 produc\u0163ia de DHT la nivelul testiculelor provine din tubii seminiferi, prin urmare, \u00een afec\u0163iuni ale tubilor seminiferi produc\u0163ia de DHT este modificat\u0103, ceea ce determin\u0103 o sc\u0103dere a nivelurilor plasmatice (pacien\u0163i cu aplazia celulelor germinale \u015fi azoospermie). La pacien\u0163ii cu anorhie nivelul seric al \u00a0DHT este foarte sc\u0103zut.<\/p>\n<p><strong>Limite \u015fi interferen\u0163e<\/strong><\/p>\n<p>DHT ar putea fi un marker important al produc\u0163iei periferice de androgeni, dar, pentru c\u0103 este metabolizat rapid \u015fi are o afinitate crescut\u0103 pentru <a href=\"https:\/\/www.synevo.ro\/shop\/shbg-sex-hormone-binding-globuline\/\" data-wpel-link=\"internal\">SHBG<\/a>, nu reflect\u0103 nivelul periferic de androgeni. \u00cen schimb, metabolitul s\u0103u, 3 \u03b1, 17 \u03b2-androstendiol glucuronid, este un indicator mai bun al concentra\u0163iei periferice de androgeni. Pacien\u0163ii cu hiperplazie benign\u0103 de prostat\u0103 sau <a href=\"https:\/\/www.synevo.ro\/cazurile-de-cancer-de-prostata\/\" data-wpel-link=\"internal\">cancer de prostat\u0103<\/a> pot s\u0103 nu aib\u0103 nivele ridicate de DHT, chiar dac\u0103 cre\u015fterea prostatei a fost stimulat\u0103 de DHT<sup>3<\/sup>.<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<div>1. IBL International. Dihydrotestosterone, Serum. www.ibl-international.com. Ref Type: Internet Communication.<\/div>\n<div>2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2023. Ref Type: Catalog.<\/div>\n<div>3. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Dihydrotestosterone (DHT). <a href=\"https:\/\/www.labcorp.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.labcorp.com<\/a> 2010. Ref Type: Internet Communication.<\/div>\n<div>4. Mayo Clinic, Mayo Medical Laboratories. Reference Laboratory Services for Health Care Organizations. Test Catalog. Dihydrotestosterone, Serum. <a href=\"https:\/\/www.mayomedicallaboratories.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">www.mayomedicallaboratories.com<\/a>. Ref Type: Internet Communication.<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Aceast\u0103 analiz\u0103 se efectueaz\u0103 conform urm\u0103toarelor specifica\u021bii\/ condi\u021bii: Bucure\u0219ti, Ilfov \u0219i zonele limitrofe: recoltarea se efectueaz\u0103 \u00een intervalul miercuri \u2013 s\u00e2mb\u0103t\u0103, \u00een timpul programului de recoltare al centrului ales. Pentru\u00a0restul \u021b\u0103rii, recoltarea se efectueaz\u0103 \u00een intervalul miercuri \u2013 vineri, \u00een timpul programului de recoltare al centrului ales. Informa\u0163ii generale Dihidrotestosteron (DHT) Dihidrotestosteronul (DHT) este un [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[71,36],"product_tag":[],"class_list":["post-218","product","type-product","status-publish","product_cat-markeri-de-fertilitate","product_cat-markeri-endochrini","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=218"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=218"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=218"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}