{"id":216,"date":"2025-06-11T12:29:58","date_gmt":"2025-06-11T12:29:58","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&p=216"},"modified":"2025-08-08T13:57:38","modified_gmt":"2025-08-08T13:57:38","slug":"hgh-hormon-de-crestere-uman","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/hgh-hormon-de-crestere-uman\/","title":{"rendered":"hGH (hormon de cre\u0219tere uman)"},"content":{"rendered":"
\n

hGH (hormon de cre\u0219tere uman): Informa\u0163ii generale<\/strong><\/h2>\n

hGH (somatotropin) este esen\u0163ial \u00een procesul de cre\u015ftere, iar la adult are un rol important \u00een activit\u0103\u0163ile metabolice. Este sintetizat \u00een celulele acidofile ale hipofizei anterioare, iar secre\u0163ia sa din granulele de depozit intracelulare este reglat\u0103 de hormonii hipotalamici GHRH (growth hormone-releasing hormone) \u015fi SRIF (somatotropin release-inhibiting factor); sinteza lor depinde de neurotransmi\u0163atori, ca serotonina, dopamina, norepinefrina \u015fi peptidele de eliberare a hormonului de cre\u015ftere.<\/p>\n

De asemenea este secretat ca r\u0103spuns la efort, stres, somn profund, hipoglicemie, glucagon, insulin\u0103, hormoni tiroidieni, estrogen, testosteron \u015fi vasopresin\u0103. \u00cen plasm\u0103 exist\u0103 \u00een mai multe isoforme monomerice \u015fi oligomeri (\u201cbig GH\u201d \u015fi \u201cbig big GH\u201d). Circul\u0103 legat de GH-binding protein, care este similar\u0103 domeniului extramembranar al receptorului tisular al hGH5<\/sup>.<\/p>\n

hGH stimuleaz\u0103 produc\u0163ia de ARN, sinteza proteic\u0103, mobilizeaz\u0103 acizii gra\u015fi din depozite \u015fi are efecte tranzitorii antagonice insulinei; niveluri crescute timp \u00eendelungat pot induce alterarea toleran\u0163ei la glucoz\u01035<\/sup>.<\/p>\n

Secre\u0163ia de hGH este pulsatil\u0103, dar la adul\u0163i concentra\u0163iile plasmatice sunt stabile, oscila\u0163iile hGH fiind atenuate de GHBP. Timpul de \u00eenjum\u0103t\u0103\u0163ire plasmatic este de 20 minute5<\/sup>.<\/p>\n

Dac\u0103 hipofiza secret\u0103 deficitar sau excesiv hGH \u00een diferite etape ale cre\u015fterii, va determina apari\u0163ia nanismului \u015fi respectiv a gigantismului. Un exces de hormon de cre\u015ftere la adult va genera acromegalie.<\/p>\n

Testul este util pentru confirmarea hipo- sau hiperpituitarismului, astfel \u00eenc\u00e2t s\u0103 poate fi ini\u0163iat\u0103 c\u00e2t mai cur\u00e2nd terapia adecvat\u0103.<\/p>\n

Determinarea hormonului se poate efectua at\u00e2t \u00een condi\u0163ii bazale c\u00e2t \u015fi dup\u0103 stimulare (efort fizic, arginin\u0103, glucagon sau insulin\u0103) sau supresie (dup\u0103 administrarea a 100 g glucoz\u0103).<\/p>\n

Absen\u0163a r\u0103spunsului sau un r\u0103spuns inadecvat la testele de stimulare se asociaz\u0103 cu hipopituitarismul.<\/p>\n

\u00cen caz de gigantism sau acromegalie, se \u00eenregistreaz\u0103 lipsa supresiei sau o supresie incomplet\u0103 dup\u0103 administrarea de glucoz\u0103. Mai mult, pacien\u0163ii cu acromegalie pot prezenta cre\u015fteri paradoxale de hGH la testul de supresie1<\/sup>.<\/p>\n

Recomand\u0103ri pentru determinarea hGH <\/strong><\/h2>\n

Diagnosticul afec\u0163iunilor hipotalamice, hipopituitarismului, acromegaliei \u015fi a produc\u0163iei ectopice de hGH de c\u0103tre anumite tumori4<\/sup>.<\/p>\n

Preg\u0103tire pacient <\/strong>\u2013 \u00e0 jeun (pe nem\u00e2ncate) \u015fi dup\u0103 cel pu\u0163in 30 minute de repaus, pentru determinarea concentra\u0163iei bazale3;4<\/sup>.<\/p>\n

Specimen recoltat <\/strong>\u2013 s\u00e2nge venos3<\/sup>.<\/p>\n

Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant, cu\/f\u0103r\u0103 gel separator3<\/sup>.<\/p>\n

Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong>\u2013 se separ\u0103 serul prin centrifugare; se lucreaz\u0103 serul imediat; dac\u0103 acest lucru nu este posibil, serul se congeleaz\u01033;4<\/sup>.<\/p>\n

Volum prob\u0103<\/strong> \u2013 minim 0.5 mL ser3<\/sup>.<\/p>\n

Cauze de respingere a probei<\/strong> \u2013 specimen intens hemolizat3<\/sup>.<\/p>\n

Stabilitate prob\u0103 <\/strong>\u2013 2 luni la -20\u00b0C; nu decongela\u0163i\/recongela\u0163i3<\/sup>.<\/p>\n

Metod\u0103 <\/strong>\u2013 ECLIA<\/u>.<\/p>\n

Valori de referin\u0163\u0103 hGH (hormon de cre\u0219tere uman)<\/strong><\/h2>\n

Sunt dependente de v\u00e2rst\u0103 \u015fi sex3<\/sup>:<\/p>\n

Fete:<\/strong><\/p>\n

0-10 ani \u2013 0,120- 7,79 ng\/ml<\/p>\n

11-17 ani \u2013 0,123- 8.05 ng\/ml<\/p>\n

Femei:<\/strong> 21-77 ani \u2013 0,126- 9.88 ng\/ml<\/p>\n

Baieti:<\/strong><\/p>\n

0-10 ani \u2013 0.094- 6.29 ng\/ml<\/p>\n

11-17 ani \u2013 0.077- 10.8 ng\/ml<\/p>\n

Barbati:<\/strong> 20-79 ani \u2013 < 2.47 ng\/ml<\/p>\n

Dupa stimulare:<\/strong><\/p>\n

>5 (fata de nivelul bazal)<\/p>\n

>10 (raspuns maximal)<\/p>\n

Dupa supresie:\u00a0 <2<\/p>\n

Limita de detectie: 0.03 ng\/ml<\/p>\n

Limite \u015fi interferen\u0163e<\/strong><\/h2>\n

O singur\u0103 determinare a hGH are o valoare limitat\u0103, datorit\u0103 fluctua\u0163iilor marcate \u00een concentra\u0163ia seric\u0103. Testele de stimulare sau supresie furnizeaz\u0103 mult mai multe informa\u0163ii.<\/p>\n

Niveluri crescute pot fi \u00eent\u00e2lnite postprandial, dup\u0103 activit\u0103\u0163i fizice, somn profund, stres, anxietate, deficit de hormoni sexuali, \u00een special androgeni, hipo-, hipertiroidism<\/a>, hiperfunc\u0163ie suprarenalian\u0103, niveluri crescute de acizi gra\u015fi liberi<\/a>; niveluri sc\u0103zute pot ap\u0103rea \u00een foame, ca\u015fexie, deficite proteice, diabet zaharat dezechilibrat metabolic5<\/sup>.<\/p>\n

\u2022 Medicamente<\/p>\n

Cre\u015fteri<\/u><\/strong>:\u00a0aminoacizi, clomipramin\u0103, clonidin\u0103, contraceptive orale, diazepam, etinil estradiol, fenitoin, indometacin, insulin\u0103, interferon, metamfetamin\u0103, metoclopramid, propranolol, vasopresin\u01032<\/sup>.<\/p>\n

Sc\u0103deri<\/strong>: acid valproic, bromocriptin\u0103, clorpromazin, corticosteroizi, hidrocortizon, medroxiprogesteron, metildopa, prednison, propantelin2<\/sup>.<\/p>\n

\u2022 Interferen\u0163e analitice<\/p>\n

Pacien\u0163ii afla\u0163i \u00een tratament cu hormon de cre\u015ftere pot dezvolta anticorpi \u00eempotriva acestui hormon, anticorpi care pot interfera cu testul conduc\u00e2nd la valori fals sc\u0103zute.<\/div>\n
Anticorpii heterofili prezen\u0163i \u00een serul pacien\u0163ilor pot interac\u0163iona cu imunoglobulinele incluse \u00een componentele din kit alter\u00e2nd rezultatele3<\/sup>.<\/div>\n

 <\/p>\n

Bibliografie<\/strong><\/h2>\n
1. Frances Fischbach. Chemistry studies. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 394-396.<\/div>\n
2. Frances Fischbach. Effects of the Most Commonly Used Drugs on Frequently Ordered Laboratory Tests. In A Manual of Laboratory and Diagnostic Tests. Lippincott Williams & Wilkins, USA, 8 Ed., 2009, 1242.<\/div>\n
3. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2024. Ref Type: Catalog.<\/div>\n
4. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Growth Hormone, Serum. www.labcorp.com<\/a>\u00a0 2015. Ref Type: Internet Communication.<\/div>\n
5. Lothar Thomas. Growth Disorders. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 1073-1074.<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

hGH (hormon de cre\u0219tere uman): Informa\u0163ii generale hGH (somatotropin) este esen\u0163ial \u00een procesul de cre\u015ftere, iar la adult are un rol important \u00een activit\u0103\u0163ile metabolice. Este sintetizat \u00een celulele acidofile ale hipofizei anterioare, iar secre\u0163ia sa din granulele de depozit intracelulare este reglat\u0103 de hormonii hipotalamici GHRH (growth hormone-releasing hormone) \u015fi SRIF (somatotropin release-inhibiting factor); […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[70,36],"product_tag":[],"class_list":["post-216","product","type-product","status-publish","product_cat-hormoni-implicati-in-procesul-de-crestere","product_cat-markeri-endochrini","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=216"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=216"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=216"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}