{"id":213,"date":"2025-06-11T12:20:20","date_gmt":"2025-06-11T12:20:20","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=213"},"modified":"2025-08-08T13:57:42","modified_gmt":"2025-08-08T13:57:42","slug":"acid-hialuronic","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/acid-hialuronic\/","title":{"rendered":"Acid hialuronic"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<h2><strong>Informa\u021bii generale Acid hialuronic<\/strong><\/h2>\n<p>Dozarea seric\u0103 de <strong>Acid hialuronic<\/strong> seric este recomandat\u0103 \u00een diagnosticarea evolu\u021biei c\u0103tre fibroza hepatic\u0103 \u0219i a severit\u0103\u021bii sale, \u00een boala ficatului gras (NAFLD). Predictor al evolu\u021biei bolii c\u0103tre ciroza hepatic\u0103.<\/p>\n<p>Nivelurile crescute de acid hialuronic (HA), un component al matricei extracelulare hepatice, sintetizat \u0219i degradat \u00een celulele sinusoidale hepatice, sunt produse de func\u021bia sc\u0103zut\u0103 a celulelor sinusoidale endoteliale. Relevan\u021ba HA \u00een boala hepatic\u0103 alcoolic\u0103 nu a fost suficient evaluat\u0103, dar se pare c\u0103 HA seric\u0103 reflect\u0103 severitatea fibrozei hepatice \u0219i fibrogeneza, precum \u0219i utilitatea poten\u021bial\u0103 a acidului hialuronic ca biomarker al fibrozei precoce si semnalizarea etapelor precirotice \u0219i cirotice la acestia.<\/p>\n<p>\u00cen mod normal, \u00een s\u00e2nge circul\u0103 concentra\u021bii sc\u0103zute de acid hialuronic, dar niveluri crescute ale acestuia apar imediat dup\u0103 leziuni majore ale \u021besuturilor. Afectarea ficatului este un exemplu de leziune major\u0103. Hialuronidaza este enzima catabolic\u0103 implicat\u0103 \u00een degradarea acidului hialuronic.<\/p>\n<p><strong>Acidul hialuronic<\/strong> (HA, hialuronat, hialuronan), distribuit \u00een spa\u021biile extracelulare, este un polizaharid liniar construit din unit\u0103\u021bi dizaharidice repetate. \u00cen ficat, acidul hialuronic este \u00een mare parte sintetizat de celulele stelate hepatice \u0219i degradat de celulele endoteliale sinusoidale<sup>1,2<\/sup>. La pacien\u021bii cu boli hepatice cronice de diferite etiologii, cre\u0219terea nivelului seric de acid hialuronic are loc odat\u0103 cu dezvoltarea fibrozei hepatice. \u00cembun\u0103t\u0103\u021birea produc\u021biei de acid hialuronic de c\u0103tre celulele stelate poate contribui la cre\u0219terea concentra\u021biilor serice de acid hialuronic observate la pacien\u021bii cu afec\u021biuni hepatice cronice f\u0103r\u0103 ciroz\u0103.<\/p>\n<p>Mai t\u00e2rziu, c\u00e2nd apare ciroza, degradarea sa redus\u0103, de c\u0103tre celulele endoteliale sinusoidale, poate determina o cre\u0219tere suplimentar\u0103 a valorii acidului hialuronic. Datele clinice au ar\u0103tat c\u0103 la pacien\u021bii cu ciroz\u0103, concentra\u021biile serice ridicate de acid hialuronic au fost asociate cu apari\u021bia complica\u021biilor \u0219i au fost corelate cu severitatea clinic\u0103<sup>3<\/sup>.<\/p>\n<p>Fiind specific \u021besuturilor articulare \u0219i fiind o component\u0103 important\u0103 a cartilajului articular \u0219i membranelor sinoviale, acidul hialuronic este un biomarker pentru sinovit\u0103 \u0219i inflama\u021biile articulare, iar valorile sale pot fi influen\u021bate de o varietate de factori, cum ar fi aportul de alimente \u0219i existen\u021ba unor inflama\u021bii<sup>4,5,6<\/sup>.<\/p>\n<h2><strong>\u00a0<\/strong><strong>Recomand\u0103ri pentru determinarea acidului hialuronic<\/strong><sup>1,4,5,6<\/sup><\/h2>\n<ul>\n<li>Pacien\u021bi cu afec\u021biuni hepatice cronice (<a href=\"https:\/\/www.synevo.ro\/fibroza-si-ciroza-hepatica\/\" data-wpel-link=\"internal\">fibroz\u0103 hepatic\u0103<\/a>);<\/li>\n<li>Biomarker pentru osteoartrita m\u00e2inii.<\/li>\n<\/ul>\n<h2><strong>Preg\u0103tire pacient<\/strong><\/h2>\n<ul>\n<li>recolta s\u00e2ngelui se realizeaz\u0103 a-jeun<\/li>\n<\/ul>\n<p><strong>Specimen recoltat \u2013 <\/strong>s\u00e2nge venos<sup>2<\/sup><\/p>\n<p><strong>Volum proba: <\/strong>1ml<\/p>\n<p><strong>Prelucrare necesar\u0103 dup\u0103 recoltare <\/strong><\/p>\n<p>Proba trebuie centrifugat\u0103 c\u00e2t mai cur\u00e2nd posibil, iar serul p\u0103strat la -20<sup>\u25e6<\/sup>C p\u00e2n\u0103 la testare<sup>2<\/sup>.<\/p>\n<p><strong>Metod\u0103 \u2013 <\/strong>ELISA<sup>1<\/sup><\/p>\n<h2><strong>Valori de referin\u021b\u0103 Acid hialuronic<\/strong><\/h2>\n<p><strong>\u00a0 <\/strong>&lt; 56,0 ng\/ml<\/p>\n<p><strong>\u00a0<\/strong><strong>\u00a0<\/strong><\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<ol>\n<li>Gu\u00e9chot J, Edrief S, Lasnier E, K\u00fcper R.(2008), <em>Automated assay of hyaluronic acid in serum<\/em>, Immuno-analyse &amp; Biologie Sp\u00e9cialis\u00e9e, Volume 23, Issue 3, Pages 148-152, ISSN 0923-2532, <a href=\"https:\/\/doi.org\/10.1016\/j.immbio.2008.02.011\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1016\/j.immbio.2008.02.011<\/a>.<\/li>\n<li>Isman FK., Kubur M., Baysal B., Ozkan F (2007<em>). Evaluation of Serum Hyaluronic Acid Level and Hyaluronidase Activity in Acute and Chronic Hepatitis C<\/em>. The Journal of International Medical Research; 35: 346 \u2013 352.<\/li>\n<li>Geramizadeh, B., Janfeshan, K., &amp; Saberfiroozi, M. (2008). <em>Serum hyaluronic acid as a noninvasive marker of hepatic fibrosis in chronic hepatitis B<\/em>. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 14(4), 174\u2013177. https:\/\/doi.org\/10.4103\/1319-3767.43274<\/li>\n<li>Saruga, T., Sasaki, E., Inoue, R. et al. <em>Usefulness of serum hyaluronic acid levels as a predictor of incidence of hand osteoarthritis analyzed by longitudinal analysis from the Iwaki cohort<\/em>. Sci Rep 11, 4074 (2021). <a href=\"https:\/\/doi.org\/10.1038\/s41598-021-83693-0\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1038\/s41598-021-83693-0<\/a>.<\/li>\n<li>Sharif, M., George, E., Shepstone, L., Knudson, W., Thonar, E. J., Cushnaghan, J., &amp; Dieppe, P. (1995). <em>Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee<\/em>. Arthritis and rheumatism, 38(6), 760\u2013767. <a href=\"https:\/\/doi.org\/10.1002\/art.1780380608\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1002\/art.1780380608<\/a><\/li>\n<li>Sasaki, E., Tsuda, E., Yamamoto, Y. et al. <em>Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis \u2013 a five-year prospective cohort study<\/em>. Arthritis Res Ther 17, 283 (2015). <a href=\"https:\/\/doi.org\/10.1186\/s13075-015-0793-0\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/doi.org\/10.1186\/s13075-015-0793-0<\/a><\/li>\n<\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Informa\u021bii generale Acid hialuronic Dozarea seric\u0103 de Acid hialuronic seric este recomandat\u0103 \u00een diagnosticarea evolu\u021biei c\u0103tre fibroza hepatic\u0103 \u0219i a severit\u0103\u021bii sale, \u00een boala ficatului gras (NAFLD). Predictor al evolu\u021biei bolii c\u0103tre ciroza hepatic\u0103. Nivelurile crescute de acid hialuronic (HA), un component al matricei extracelulare hepatice, sintetizat \u0219i degradat \u00een celulele sinusoidale hepatice, sunt produse [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[68,35],"product_tag":[],"class_list":["post-213","product","type-product","status-publish","product_cat-markeri-non-invazivi-pentru-afectiunile-hepatice","product_cat-teste-de-biochimie","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=213"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=213"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=213"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}