{"id":212,"date":"2025-06-11T12:19:14","date_gmt":"2025-06-11T12:19:14","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=212"},"modified":"2025-08-08T13:57:43","modified_gmt":"2025-08-08T13:57:43","slug":"cdt-transferina-deficitara-in-carbohidrat","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/cdt-transferina-deficitara-in-carbohidrat\/","title":{"rendered":"CDT (transferina deficitar\u0103 \u00een carbohidrat)"},"content":{"rendered":"<div class=\"info-content content-informatii-generale\">\n<h2><strong>Informa\u0163ii generale \u2013 CDT (transferina deficitar\u0103 \u00een carbohidrat)<\/strong><\/h2>\n<p>Transferina este o glicoprotein\u0103 plasmatic\u0103 care transport\u0103 fierul la receptorii celulari specifici. Din punct de vedere structural este un polipeptid ce prezint\u0103 la cap\u0103tul amino-terminal dou\u0103 lan\u0163uri polizaharidice.<\/p>\n<p>Aceste dou\u0103 lan\u0163uri se ramific\u0103 form\u00e2nd 2 sau 3 structuri antenare ce au ca reziduu terminal acidul sialic, determin\u00e2nd astfel existen\u0163a a 4 izoforme: pentasialo, tetrasialo, trisialo \u015fi disialo. Izoforma disialo reprezint\u0103, la persoanele normale, mai pu\u0163in de 1%, dar cre\u015fte de 10-15 ori la marii consumatori de alcool, la care mai apare \u015fi o form\u0103 special\u0103, asialo. Frac\u0163ia disialo \u00eempreun\u0103 cu cea asialo formeaz\u0103 transferina deficitar\u0103 \u00een carbohidrat.<\/p>\n<p>\u00cen compara\u0163ie cu al\u0163i parametrii disponibili pentru diagnosticarea abuzului cronic de alcool CDT s-a dovedit a avea cea mai mare specificitate, fiind un marker important \u00een identificarea \u015fi monitorizarea consumatorilor cronici de alcool<sup>1;3<\/sup>.<\/p>\n<h2><strong>Recomand\u0103ri pentru determinarea CDT<\/strong><\/h2>\n<ul>\n<li>screening-ul persoanelor suspectate de <a href=\"https:\/\/www.synevo.ro\/alcoolism-si-boala-etanolica\/\" target=\"_blank\" rel=\"noopener\" data-wpel-link=\"internal\">abuz de alcool<\/a>, la care alte teste sunt negative;<\/li>\n<li>identificarea alcoolicilor cronici dintre persoanele traumatizate, pentru a preveni complica\u0163iile posttraumatice; <strong>\u00a0<\/strong><\/li>\n<li>dentificarea persoanelor cu risc de a dezvolta dependen\u0163\u0103;<\/li>\n<li>monitorizarea pe termen lung a rec\u0103derilor la pacien\u0163ii afla\u0163i sub tratament<sup>3<\/sup>.<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<h2><strong>Preg\u0103tire pacient <\/strong><\/h2>\n<p>nu este necesar\u0103 nici o preg\u0103tire special\u0103 a pacientului<sup>2<\/sup>.<\/p>\n<p><strong>Specimen recoltat <\/strong>\u2013 s\u00e2nge venos<sup>2<\/sup>.<\/p>\n<p><strong>Recipient de recoltare <\/strong>\u2013 vacutainer f\u0103r\u0103 anticoagulant cu\/f\u0103r\u0103 gel separator<sup>2<\/sup>.<\/p>\n<p><strong>Prelucrare necesar\u0103 dup\u0103 recoltare<\/strong> \u2013 se separ\u0103 serul prin centrifugare<sup>2<\/sup>.<\/p>\n<p><strong>Volum prob\u0103<\/strong> \u2013 minim 0.5 mL ser<sup>2<\/sup>.<\/p>\n<p><strong>Cauze de respingere a probei <\/strong>\u2013 specimen hemolizat<sup>2<\/sup>.<\/p>\n<p><strong>Stabilitate prob\u0103<\/strong> \u2013 2 saptamani la -20\u00b0C<sup>2<\/sup>.<\/p>\n<p><strong>Metod\u0103 <\/strong>\u2013 cromatografie de lichide sub \u00eenalt\u0103 presiune (HPLC)<sup>2<\/sup>.<\/p>\n<h2><strong>Valori de referin\u0163\u0103 CDT (transferina deficitar\u0103 \u00een carbohidrat)<\/strong><\/h2>\n<p>&lt;1.75%<sup>2<\/sup>.<\/p>\n<h2><strong>Interpretarea rezultatelor<\/strong><\/h2>\n<div>Cre\u015fterea CDT (&gt;3 %) reprezint\u0103 un marker pentru abuzul cronic de alcool (specificitate &gt; 90%). Sensibilitatea este 75% pentru b\u0103rba\u0163i \u015fi 50% pentru femei.<\/div>\n<div>Un episod singular de abuz de alcool nu duce la cre\u015fterea concentra\u0163iei CDT. Cantitatea minim\u0103 de alcool care determin\u0103 cre\u015fterea CDT este de 50-80 g etanol\/zi, cel pu\u0163in 7 zile consecutiv. Dup\u0103 abstinen\u0163\u0103, valorile se men\u0163in ridicate timp de 2-4 s\u0103pt\u0103m\u00e2ni.<\/div>\n<div><\/div>\n<div>P\u00e2n\u0103 acum nu s-a dovedit c\u0103 ar exista o rela\u0163ie liniar\u0103 \u00eentre valoarea CDT \u015fi cantitatea de alcool consumat\u0103, totu\u015fi este clar c\u0103 valori ridicate ale CDT sunt legate de un consum abuziv de alcool.<\/div>\n<div>Valori crescute ale CDT se pot g\u0103si \u015fi \u00een hepatita cronic\u0103 activ\u0103, carcinom hepato-celular, ciroza biliar\u0103 primitiv\u0103, sarcin\u0103 \u015fi \u00een sindromul foarte rar de deficit de carbohidrat\u2013glicoprotein\u0103, condi\u0163ionat genetic.<\/div>\n<div><\/div>\n<div>Valori cuprinse \u00eentre 1.75 \u015fi 3% nu pot indica cu certitudine abuzul de alcool \u015fi necesit\u0103 monitorizare<sup>2;3<\/sup>.<\/div>\n<div><\/div>\n<div><strong>Limite \u015fi interferente<\/strong><\/div>\n<div>\u00cen prezen\u0163a unei variante de transferin\u0103 modificat\u0103 genetic CDT nu poate fi estimat\u0103<sup>2<\/sup> .<\/div>\n<p>&nbsp;<\/p>\n<p><strong>Bibliografie<\/strong><\/p>\n<div>1. ARUP Laboratories. Test Directory: Carbohydrate Deficient Transferrin. www.aruplab.com 2010. Ref Type: Internet Communication.<\/div>\n<div>2. Laborator Synevo. Referin\u0163ele specifice tehnologiei de lucru utilizate. 2010. Ref Type: Catalog.<\/div>\n<div>3. Lothar Thomas. Carbohydrate Deficient Transferrin. In Clinical Laboratory Diagnostics-Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt \/Main, Germany, 1 Ed., 1998, 656-459.<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Informa\u0163ii generale \u2013 CDT (transferina deficitar\u0103 \u00een carbohidrat) Transferina este o glicoprotein\u0103 plasmatic\u0103 care transport\u0103 fierul la receptorii celulari specifici. Din punct de vedere structural este un polipeptid ce prezint\u0103 la cap\u0103tul amino-terminal dou\u0103 lan\u0163uri polizaharidice. Aceste dou\u0103 lan\u0163uri se ramific\u0103 form\u00e2nd 2 sau 3 structuri antenare ce au ca reziduu terminal acidul sialic, determin\u00e2nd [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[35,67],"product_tag":[],"class_list":["post-212","product","type-product","status-publish","product_cat-teste-de-biochimie","product_cat-transferina-carbohidrat-deficitara-cdt-marker-pentru-alcoolism","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=212"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=212"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=212"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}