{"id":206,"date":"2025-06-11T12:11:03","date_gmt":"2025-06-11T12:11:03","guid":{"rendered":"https:\/\/analizesanocare.ro\/?post_type=product&#038;p=206"},"modified":"2025-08-08T13:57:57","modified_gmt":"2025-08-08T13:57:57","slug":"adenozin-deaminaza-ada-in-lichid-de-punctie","status":"publish","type":"product","link":"https:\/\/analizesanocare.ro\/en\/analiz\u0103\/adenozin-deaminaza-ada-in-lichid-de-punctie\/","title":{"rendered":"Adenozin deaminaza (ADA) in lichid de punctie"},"content":{"rendered":"<h2><b>Informa\u021bii generale Adenozin deaminaza (ADA) in lichid de punctie<\/b><\/h2>\n<p>Determinarea de <strong>a<\/strong><strong>denozin-dezaminaza (ADA) in lichidul de punctie<\/strong> (peritoneal sau cefalorahidian \u2013 LCR ) este recomandat\u0103 pentru diagnosticarea sau excluderea unei infec\u021bii cu Mycobacterium tuberculosis \u00een lichidul pleural.<\/p>\n<p>Adenozin deaminaza (ADA) este considerat\u0103 un indicator pentru reac\u021bia imunologic\u0103 mediat\u0103 celular. Se g\u0103se\u0219te \u00een principal \u00een limfocitele T dec\u00e2t \u00een \u200b\u200blimfocitele B \u0219i tinde s\u0103 scad\u0103 pe m\u0103sur\u0103 ce se produce maturarea celulelor T<sup>1<\/sup>. ADA este o enzim\u0103 care catalizeaz\u0103 degradarea adenozinei \u00een inozin\u0103 \u0219i ammoniac. Determinarea activit\u0103\u021bii ADA \u00een fluidele pleurale, fluide peritoneale \u0219i fluide pericardice este util\u0103 \u00een diagnosticul <a href=\"https:\/\/www.synevo.ro\/?search=tuberculoza&amp;is_v=1\" target=\"_blank\" rel=\"noopener\" data-wpel-link=\"internal\">infec\u021biei tuberculoase<\/a>. Func\u021bia fiziologic\u0103 principal\u0103 a ADA este legat\u0103 de proliferarea \u0219i diferen\u021bierea limfocitar\u0103<sup>2<\/sup>.<\/p>\n<p>Ca un marker al imunit\u0103\u021bii celulare, se constat\u0103 c\u0103 activitatea ADA este crescut\u0103 \u00een acele boli \u00een care exist\u0103 un r\u0103spuns imun mediat celular. Numeroase studii anterioare au demonstrat c\u0103 estimarea LCR-ADA este util\u0103 \u00een <a href=\"https:\/\/www.synevo.ro\/meningita-virala-importanta-diagnosticului-diferential\/\" data-wpel-link=\"internal\">diagnosticul meningitelor<\/a> (de ex. meningita piocianic\u0103)<sup>3,4<\/sup>.<\/p>\n<p>Deficitul de adenozin deaminaz\u0103 (ADA) duce la o acumulare de subproduse toxice ale degrad\u0103rii purinei, afect\u00e2nd cel mai puternic limfocitele, conduc\u00e2nd la imunodeficien\u021b\u0103 combinat\u0103 sever\u0103 cu adenozin deaminaz\u0103. \u00cen timp ce efectele cele mai notabile sunt asupra limfocitelor, alte manifest\u0103ri includ anomalii scheletice, afect\u0103ri ale neurodezvolt\u0103rii \u0219i manifest\u0103ri pulmonare asociate cu proteinoza pulmonar-alveolar\u0103.<\/p>\n<p>Recomand\u0103ri pentru determinarea adenozin deaminaza (ADA) \u00een lichid de punc\u021bie<sup>5<\/sup><\/p>\n<ul>\n<li>Pacien\u021bi cu infec\u021bii persistente<\/li>\n<li>Pacien\u021bi cu insuficien\u021b\u0103 pulmonar\u0103<\/li>\n<\/ul>\n<p><b>Specimen recoltat\u00a0\u2013 <\/b>lichid cefalo-rahidian<sup>3<\/sup><\/p>\n<p><b>Recipient de recoltare\u00a0\u2013 <\/b>recipient etan\u0219, steril<sup>3<\/sup>.<\/p>\n<p><b>Prelucrare necesar\u0103 dup\u0103 recoltare<\/b><\/p>\n<p>Specimenul se centrifugheaz\u0103 la temperatura camerei<sup>6<\/sup>.<\/p>\n<p><b>Volum prob\u0103\u00a0\u2013 <\/b>1 mL<\/p>\n<p><b>Cauze de respingere a probei\u00a0\u2013 <\/b>Specimene tulburi, prezen\u021ba s\u00e2ngelui, recolt\u0103ri \u00een tuburi neadecvate<sup>6<\/sup><\/p>\n<p><b>Stabilitate prob\u0103\u00a0<\/b><\/p>\n<p>Proba are stabilitate timp de 30 de zile la congelator (preferabil), 7 zile \u00een frigider \u0219i 24 de ore la temperature camerei<sup>6<\/sup>.<\/p>\n<p><b>Metod\u0103\u00a0\u2013 <\/b>Spectrofotometrie cantitativ\u0103<sup>6<\/sup><\/p>\n<h2><b>Valori de referin\u021b\u0103 Adenozin deaminaza (ADA) in lichid de punctie<\/b><\/h2>\n<p><b> <\/b>0-9 U\/L<sup>6<\/sup><\/p>\n<h2><strong>Bibliografie<\/strong><\/h2>\n<ol>\n<li>Cho BH, Kim BC, Yoon GJ, Choi SM, Chang J, Lee SH, Park MS, Shin JH, Kim MK, Cho KH<em>. Adenosine deaminase activity in cerebrospinal fluid and serum for the diagnosis of tuberculous meningitis.<\/em> Clin Neurol Neurosurg. 2013 Sep;115(9):1831-6. doi: 10.1016\/j.clineuro.2013.05.017. Epub 2013 Jun 12. PMID: 23768730.<\/li>\n<li>Flinn AM, Gennery AR. Adenosine deaminase deficiency: a review. Orphanet J Rare Dis. 2018 Apr 24;13(1):65. doi: 10.1186\/s13023-018-0807-5. PMID: 29690908; PMCID: PMC5916829.<\/li>\n<li>Kohn DB, Hershfield MS, Puck JM, Aiuti A, Blincoe A, Gaspar HB, Notarangelo LD, Grunebaum E. Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency. J Allergy Clin Immunol. 2019 Mar;143(3):852-863. doi: 10.1016\/j.jaci.2018.08.024. Epub 2018 Sep 5. PMID: 30194989; PMCID: PMC6688493.<\/li>\n<li>Bagheri S, Saboury AA, Haertl\u00e9 T. Adenosine deaminase inhibition. Int J Biol Macromol. 2019 Dec 1;141:1246-1257. doi: 10.1016\/j.ijbiomac.2019.09.078. Epub 2019 Sep 11. PMID: 31520704.<\/li>\n<li>Kashyap RS, Kainthla RP, Mudaliar AV, Purohit HJ, Taori GM, Daginawala HF. <em>Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis.<\/em> Cerebrospinal Fluid Res. 2006 Mar 30;3:5. doi: 10.1186\/1743-8454-3-5. PMID: 16571142; PMCID: PMC1448186.<\/li>\n<li>Mayo Clinic. Mayo Medical Laboratories. Test Catalog. [on-line]: <a href=\"https:\/\/www.mayocliniclabs.com\" target=\"_blank\" rel=\"noopener nofollow external noreferrer\" data-wpel-link=\"external\">https:\/\/www.mayocliniclabs.com<\/a> [Accesat la data de 11.03.2021]<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Informa\u021bii generale Adenozin deaminaza (ADA) in lichid de punctie Determinarea de adenozin-dezaminaza (ADA) in lichidul de punctie (peritoneal sau cefalorahidian \u2013 LCR ) este recomandat\u0103 pentru diagnosticarea sau excluderea unei infec\u021bii cu Mycobacterium tuberculosis \u00een lichidul pleural. Adenozin deaminaza (ADA) este considerat\u0103 un indicator pentru reac\u021bia imunologic\u0103 mediat\u0103 celular. Se g\u0103se\u0219te \u00een principal \u00een limfocitele [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[61,35],"product_tag":[],"class_list":["post-206","product","type-product","status-publish","product_cat-teste-biochimice-din-lichide-de-punctie","product_cat-teste-de-biochimie","first","instock","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product\/206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:attachment":[{"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/media?parent=206"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_brand?post=206"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_cat?post=206"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/analizesanocare.ro\/en\/wp-json\/wp\/v2\/product_tag?post=206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}